Yangonin
Yangonin structure
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Common Name | Yangonin | ||
|---|---|---|---|---|
| CAS Number | 500-62-9 | Molecular Weight | 258.269 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 487.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H14O4 | Melting Point | 155-157ºC | |
| MSDS | Chinese USA | Flash Point | 219.7±28.8 °C | |
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Fatal kavalactone intoxication by suicidal intravenous injection.
Forensic Sci. Int. 249 , e7-11, (2015) Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxiolytic and sedative properties. Sales of kava extracts were se... |
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Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
Planta Med. 67(4) , 306-11, (2001) Methanolic leaf and root extracts of the Hawaiian kava (Piper methysticum Forst.) cultivars, Mahakea, Nene, Purple Moi and PNG, were tested on binding affinities to CNS receptors including GABAA (GABA and benzodiazepine binding site), dopamine D2, opioid (mu ... |
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Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
Phytomedicine 13(3) , 192-5, (2006) In recent years, Kava kava (Piper methysticum, Forst. f., Piperaceae), a folkloric beverage and popular herbal remedy, has been implicated in a number of liver failure cases. Many hypotheses as to the mechanism of its hepatotoxicity, for example interactions ... |
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In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones.
Toxicol. Sci. 79(1) , 106-11, (2004) Kava herbal supplements have been recently associated with acute hepatotoxicity, leading to the ban of kava products in approximately a dozen countries around the world. It is suspected that some alkaloids from aerial kava may have contributed to the problem.... |
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Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.
Phytother Res. 25(3) , 417-23, (2011) While cases of severe kava hepatotoxicity have been reported, studies examining the toxicity of individual kavalactones are limited. The present study examined the in vitro hepatotoxicity of kavain, methysticin and yangonin on human hepatocytes (HepG2) and th... |
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Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum).
Phytomedicine 10(4) , 309-17, (2003) Two unique evidence that cancer incidence rates in Fiji were unusually low, compared with those of another Pacific islands and that green tea beverage is an acknowledged cancer preventive in Japan, allowed us to study a local beverage in Fiji, kawa (kava kava... |
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Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
Phytomedicine 11(4) , 285-94, (2004) The effects of the herbal product kava (Kava kava, 'Awa, Yaqona, Piper methysticum) on human P450 isoforms were studied in vitro using both cDNA-expressed human enzymes and cryopreserved human hepatocytes. Increasing concentrations of an ethanolic extract of ... |
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Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products.
Phytomedicine 9(3) , 263-7, (2002) To evaluate the effects of intrinsic (natural) fluorescence and quenching as confounding variables in fluorescence-based enzyme inhibition assays of natural products, we measured the fluorescence and quenching properties of 25 components of popular herbal pro... |
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Contribution to the quantitative and enantioselective determination of kavapyrones by high-performance liquid chromatography on ChiraSpher NT material.
J. Chromatogr. B. Biomed. Sci. Appl. 702(1-2) , 240-4, (1997) A simultaneous HPLC separation of the enantiomers of kavain, dihydrokavain, methysticin and dihydromethysticin, as well as the achiral dienolides yangonin and desmethoxyyangonin was carried out on a ChiraSpher NT column. For quantitative determinations, calib... |
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Permeability studies of Kavalactones using a Caco-2 cell monolayer model.
J. Clin. Pharm. Ther. 32(3) , 233-9, (2007) To examine the bioavailability of kavalactones in vitro and the possible differences in their bioavailability because of variations in either chemical structure or the method of extraction used.Caco-2 cell monolayers were used to determine the potential bioav... |