Methylboronic acid

Nucl. Med. Biol. 41(10) , 813-24, (2014)

(99m)Tc-Teboroxime ([(99m)TcCl(CDO)(CDOH)2BMe]) is a member of the BATO (boronic acid adducts of technetium dioximes) class of (99m)Tc(III) complexes. This study sought to explore the impact of co-ligands on solution stability, heart uptake and myocardial ret...

J. Am. Chem. Soc. 44th ed., 132 , 15474-15476, (2010)

A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of γ-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective ...

J. Am. Chem. Soc. 133 , 9164-9167, (2011)

A facile and efficient enantioselective bromoaminocyclization of unsaturated sulfonamides has been developed using an amino-thiocarbamate catalyst. A range of enantioenriched pyrrolidines were prepared with up to 99% yield and 99% ee. The corresponding lactam...

J. Am. Chem. Soc. 18th ed., 133 , 7222-7228, (2011)

Modern drug discovery is contingent on identifying lead compounds and rapidly synthesizing analogues. The use of a common pharmacophore to direct multiple and divergent C-H functionalizations of lead compounds is a particularly attractive approach. Herein, we...

Chem. Commun. (Camb.) 9th ed., 48 , 1230-1232, (2012)

Palladium-catalyzed cross-coupling reactions of secondary allylic boronic esters with iodoarenes were demonstrated under the conditions previously described for the coupling of benzylic substrates. The regioselectivity of the process was largely dictated by t...

J. Org. Chem. 70 , 10124, (2005)

[reaction: see text] Herein we demonstrate functionalized enol tosylates to be robust substrates that undergo Suzuki-Miyaura, Sonogashira, and Stille cross-coupling reactions to provide stereodefined trisubstituted unsaturated esters.

Eur. J. Med. Chem. 9th ed., 46 , 4657-4660, (2011)

A number of 8-substituted chrysin analogs have been prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E(2) and iNOS-mediated NO production. Analogs were prepared via Suzuki-Miyaura C-C cross coupling reaction o...

Synlett , 1351, (2006)

Bull. Chem. Soc. Jpn. 10th ed., 84 , 1136-1143, (2011)

Chem. Lett. 9th ed., 40 , 916-918, (2011)