Diflunisal
Diflunisal structure
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Common Name | Diflunisal | ||
|---|---|---|---|---|
| CAS Number | 22494-42-4 | Molecular Weight | 250.198 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 386.9±42.0 °C at 760 mmHg | |
| Molecular Formula | C13H8F2O3 | Melting Point | 32-36 °C | |
| MSDS | Chinese USA | Flash Point | 187.8±27.9 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-tumor agents.
Bioorg. Med. Chem. Lett. 19(15) , 4399-402, (2009) To discover the new medicinal activity, the structure of diflunisal has been modified. Forty amide derivatives of diflunisal were synthesized starting from diflunisal in three steps. Their inhibition growth rate of human lung cancer cell (A549) and human endo... |
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Evaluation of the drug-polymer interaction in calcium alginate beads containing diflunisal.
Pharmazie 65(2) , 106-9, (2010) Calcium alginate gel beads have been developed in recent years as a unique vehicle for oral drug delivery due to their excellent biocompatibility, biodegradability, simple method of preparation, abundant sources, low cost and minimal processing requirements. ... |
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Simultaneous determination of ezetimibe and simvastatin in pharmaceutical preparations by MEKC.
J. Chromatogr. Sci. 48(2) , 95-9, (2010) A micellar electrokinetic capillary chromatography method was developed and validated for the simultaneous determination of ezetimibe and simvastatin in pharmaceutical preparations. The influence of buffer concentration, buffer pH, sodium dodecyl sulphate (SD... |
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Simultaneous determination of the two non-steroidal anti-inflammatory drugs ; diflunisal and naproxen in their tablets by chemometric spectrophotometry and HPLC.
Pak. J. Pharm. Sci. 22(1) , 8-17, (2009) Chemometric spectrophotometry and HPLC were applied to the simultaneous determination of the two non-steroidal anti-inflammatory drugs; diflunisal (I) and naproxen (II). The applied chemometric techniques are multivariate methods including classical least squ... |
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Cyclodextrin-crosslinked poly(acrylic acid): adhesion and controlled release of diflunisal and fluconazole from solid dosage forms.
AAPS PharmSciTech 14(1) , 301-11, (2013) The controlled release of diflunisal and fluconazole from tablets made of novel polymers, poly(acrylic acid) (PAA) crosslinked with either β-cyclodextrin (βCD) or hydroxypropyl-βCD (HPβCD), was investigated and Carbopol 934P (Carbopol) was used as a highly cr... |
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A new hydrate form of diflunisal precipitated from a microemulsion system
Colloids Surf. B Biointerfaces 109 , 68-73, (2013) Three microemulsion systems were applied as solvents for polymorph screening of seven active pharmaceutical ingredients (APIs): carbamazepine, piroxicam, sulfaguanidine, nitrofurantoin, theophylline, quercetin, and diflunisal. All the recrystallized compounds... |
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Differential scanning calorimetry study on drug release from an inulin-based hydrogel and its interaction with a biomembrane model: pH and loading effect.
Eur. J. Pharm. Sci. 35(1-2) , 76-85, (2008) Inulin has been derivatized with methacrylic anhydride (MA) and succinic anhydride (SA) to obtain a methacrylated/succinilated derivative (INU-MA-SA) able to produce a pH sensitive hydrogel after UV irradiation. The hydrogel was characterized and loaded with ... |
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Simultaneous determination of two anti-inflammatory drugs in serum using isopotential fluorimetry.
Anal. Chim. Acta 625(1) , 47-54, (2008) The simultaneous determination of 6-methoxy-2-naphthylacetic acid (6MNA) and diflunisal in serum samples using the combination of matrix isopotential synchronous fluorescence (MISF) and first derivative technique is proposed. 6MNA and diflunisal exhibit overl... |
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Single dose oral diflunisal for acute postoperative pain in adults.
Cochrane Database Syst. Rev. (4) , CD007440, (2010) Diflunisal is a long-acting non-steroidal anti-inflammatory drug (NSAID) most commonly used to treat acute postoperative pain or chronic joint pain from osteoarthritis and rheumatoid arthritis. This review analyses the effectiveness and harm of different dose... |
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Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease.
PLoS ONE 7(9) , e45368, (2012) Transthyretin (TTR) protects against A-Beta toxicity by binding the peptide thus inhibiting its aggregation. Previous work showed different TTR mutations interact differently with A-Beta, with increasing affinities correlating with decreasing amyloidogenecity... |