Paeonol
Paeonol structure
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Common Name | Paeonol | ||
|---|---|---|---|---|
| CAS Number | 552-41-0 | Molecular Weight | 166.174 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 301.9±22.0 °C at 760 mmHg | |
| Molecular Formula | C9H10O3 | Melting Point | 48-50 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 122.3±15.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Competitive molecular interaction among paeonol-loaded liposomes: differential scanning calorimetry and synchrotron X-ray diffraction studies.
Int. J. Pharm. 438(1-2) , 91-7, (2012) Thermotropic phase behavior of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes containing 5 mol% cholesterol, or 5 mol% stigmasterol, or 5 mol% paeonol have been investigated by differential scanning calorimetry (DSC) and synchrotron X-ray diffra... |
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Paeonol inhibits oxidized low density lipoprotein-induced monocyte adhesion to vascular endothelial cells by inhibiting the mitogen activated protein kinase pathway.
Biol. Pharm. Bull. 35(5) , 767-72, (2012) Atherosclerosis is a chronic inflammatory disease characterized by increased expression of adhesion molecules, which contribute to monocytes adhesion to vascular endothelial cells (VECs). Paeonol, an active compound isolated from cortex Moutan, has been shown... |
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Influence of co-administered danshensu on pharmacokinetic fate and tissue distribution of paeonol in rats.
Planta Med. 78(2) , 135-40, (2012) Cortex Moutan (root bark of Paeonia suffruticosa Andrew) and Radix Salviae miltiorrhizae (root and rhizome of Salvia miltiorrhiza Bunge) are two herbs widely used in traditional Chinese medicine (TCM) to treat cerebrovascular and cardiovascular diseases. In c... |
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Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.
Molecules 17(4) , 4672-83, (2012) The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results sh... |
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Cardioprotective effect of paeonol and danshensu combination on isoproterenol-induced myocardial injury in rats.
PLoS ONE 7(11) , e48872, (2012) Traditional Chinese medicinal herbs Cortex Moutan and Radix Salviae Milthiorrhizaeare are prescribed together for their putative cardioprotective effects in clinical practice. However, the rationale of the combined use remains unclear. The present study was d... |
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Simultaneous determination of danshensu, salvianolic acid B, and paeonol in ShuangDan oral liquid by HPLC.
J. AOAC Int. 96(1) , 20-3, (2013) An HPLC-photodiode array detector (PDAD) method was developed for simultaneous determination of danshensu, salvianolic acid B, and paeonol in a traditional Chinese medicinal preparation ShuangDan oral liquid, which is widely used to treat coronary heart disea... |
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Transdermal delivery of paeonol using cubic gel and microemulsion gel.
Int. J. Nanomedicine 6 , 1603-10, (2011) The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations.Various microemulsion vehicles were prepared using isopropyl myristate as an oil phase, polyoxyethylated castor oi... |
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Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor.
Nat. Prod. Commun. 6(8) , 1129-30, (2011) Biotransformation of paeonol (1) with the white-rot basidiomycete Coriolus versicolor afforded two metabolites, 2,4-dihydroxyacetophenone (2) and 2,5-dihydroxy-4-methoxyacetophenone (3), which were identified by spectroscopic methods. Compound 3 showed higher... |
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The joint action of destruxins and botanical insecticides (rotenone, azadirachtin and paeonolum) against the cotton aphid, Aphis gossypii Glover.
Molecules 17(6) , 7533-42, (2012) The joint action of destruxins and three botanical insecticides, rotenone (Rot), azadirachtin (Aza) and paeonolum (Pae) against the cotton aphid, Aphis gossypii, was bioassayed. In laboratory experiment, several synergistic groups of destruxins with botanical... |
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Quality control of modified xiaoyao san through the determination of 22 active components by ultra-performance liquid chromatography.
J. AOAC Int. 94(6) , 1778-84, (2011) A simple, sensitive, and reliable ultra-performance liquid chromatography (UPLC) method has been developed for simultaneous determination of 22 major constituents in modified xiaoyao san (MXS), a multiherbal formula. The chromatographic separation was perform... |