N-1-Naphthylethylenediamine dihydrochloride
N-1-Naphthylethylenediamine dihydrochloride structure
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Common Name | N-1-Naphthylethylenediamine dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1465-25-4 | Molecular Weight | 259.175 | |
| Density | N/A | Boiling Point | 370.7ºC at 760 mmHg | |
| Molecular Formula | C12H16Cl2N2 | Melting Point | 200 °C | |
| MSDS | Chinese USA | Flash Point | 209.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation.
Life Sci. 130 , 31-7, (2015) This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage t... |
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Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.
PLoS ONE 10(1) , e0117842, (2015) Mouse cytochrome P450 (CYP) 2A5 is induced by inflammatory conditions and infectious diseases that down-regulate the expression and activity of most other CYP isoforms. Enhanced oxidative stress and nuclear factor (erythroid 2-related factor) 2 (Nrf2) transcr... |
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N-(1-naphthyl) ethylenediamine dinitrate: a new matrix for negative ion MALDI-TOF MS analysis of small molecules.
J. Am. Soc. Mass Spectrom. 23(9) , 1454-60, (2012) An organic salt, N-(1-naphthyl) ethylenediamine dinitrate (NEDN), with rationally designed properties of a strong UV absorbing chromophore, hydrogen binding and nitrate anion donors, has been employed as a matrix to analyze small molecules (m/z < 1000) such a... |
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Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.
Microbes Infect. 17(3) , 184-94, (2015) In malaria, the evidence concerning the nucleotide-binding, oligomerization domain (NOD) 2 (NOD2) receptor is fragmented and the stimuli that might activate NOD2 are not well characterized. We investigated the role of NOD2 in vitro in the response of macropha... |
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Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages.
BMC Immunol. 16 , 38, (2015) Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope... |
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Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation.
Free Radic. Res. 49(3) , 269-78, (2015) Overexpression of cyclooxygenase 2 (COX-2) by stromal fibroblasts plays a critical role in the early stage of carcinogenesis. COX-2 expression is thought to be positively or negatively regulated by inflammatory chemical mediators or tumor suppressors. In this... |
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Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells.
PLoS ONE 10 , e0141897, (2015) Camptothecin (CPT), a topoisomerase I poison, is an important drug for the treatment of solid tumors in the clinic. Nitric oxide (·NO), a physiological signaling molecule, is involved in many cellular functions, including cell proliferation, survival and deat... |
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Microparticles of rifampicin: comparison of pulmonary route with oral route for drug uptake by alveolar macrophages, phagocytosis activity and toxicity study in albino rats.
Drug Deliv. 21(6) , 406-11, (2014) Tuberculosis (TB) is a chronic infectious disease with increasing incidence of drug resistance. Oral treatment for TB and multidrug resistance (MDR)-TB can have serious side effects. The causative agent of TB, Mycobacterium tuberculosis, resides in alveolar m... |
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Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation.
Brain Res. Bull. 112 , 25-34, (2015) Neuroinflammation is one of the critical pathological mechanisms influencing various neurodegenerative disorders. Most of the neurodegenerative diseases involve over-activation of microglial cells contributing to the demise of neurons. The objective of the cu... |
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Secoiridoid glycosides from the root of Gentiana crassicaulis with inhibitory effects against LPS-induced NO and IL-6 production in RAW264 macrophages.
J. Nat. Med. 69 , 366-74, (2015) The root of Gentiana crassicaulis has been widely used for the treatment of rheumatism, arthralgia, apoplexy, jaundice and diabetes in traditional medicines, and contains secoiridoid glycosides as the main active ingredients. In the present study, five new se... |