Dimethyl fumarate
Dimethyl fumarate structure
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Common Name | Dimethyl fumarate | ||
|---|---|---|---|---|
| CAS Number | 624-49-7 | Molecular Weight | 144.125 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 193.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C6H8O4 | Melting Point | 102-106 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 91.1±0.0 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Novel Nrf2 activators from microbial transformation products inhibit blood-retinal barrier permeability in rabbits.
Br. J. Pharmacol. 172(5) , 1237-49, (2015) Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that binds to antioxidant response elements located in the promoter region of genes encoding many antioxidant enzymes and phase II detoxifying enzymes. Activation of ... |
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Quantitative determination of dimethyl fumarate in silica gel by solid-phase microextraction/gas chromatography/mass spectrometry and ultrasound-assisted extraction/gas chromatography/mass spectrometry.
Environ. Monit. Assess. 187 , 320, (2015) Dimethyl fumarate (DMF) is a chemical compound which has been added to silica gel bags used for preserving leather products during shipment. DMF has recently been singled out due to its ability to induce a number of medical problems in people which touch prod... |
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Cold stress initiates the Nrf2/UGT1A1/L-FABP signaling pathway in chickens.
Poult. Sci. 94 , 2597-603, (2015) Cold stress triggers an anti-oxidative response in animals regulated by Nrf2 (nuclear factor 2-like, NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes. To identify chicken Nrf2-regulated genes, 3 genetically related ex... |
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Synthesis of Unsaturated Polyester Resins from Various Bio-Derived Platform Molecules.
Int. J. Mol. Sci. 16 , 14912-32, (2015) Utilisation of bio-derived platform molecules in polymer synthesis has advantages which are, broadly, twofold; to digress from crude oil dependence of the polymer industry and secondly to reduce the environmental impact of the polymer synthesis through the in... |
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Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway.
Int. J. Mol. Sci. 16 , 13885-907, (2015) Multiple sclerosis (MS) is the most common multifocal inflammatory demyelinating disease of the central nervous system (CNS). Due to the progressive neurodegenerative nature of MS, developing treatments that exhibit direct neuroprotective effects are needed. ... |
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Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.
PLoS ONE 9(6) , e98385, (2014) Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon doub... |
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Effects of fumaric acid esters on blood-brain barrier tight junction proteins.
Neurosci. Lett. 555 , 165-70, (2013) The blood-brain barrier (BBB) is composed of a network of tight junctions (TJ) which interconnect cerebral endothelial cells (EC). Alterations in the TJ proteins are common in inflammatory diseases of the central nervous system (CNS) like multiple sclerosis (... |
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Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts.
J. Allergy (Cairo.) 2011 , 457169, (2011) Rhinovirus-(RV-) induced asthma exacerbations account for high asthma-related health costs and morbidity in Australia. The cellular mechanism underlying this pathology is likely the result of RV-induced nuclear-factor-kappa-B-(NF-κB-) dependent inflammation. ... |
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Chemistry of Ru(eta6-1,3,5-cyclooctatriene)(eta2-dimethyl fumarate)2.
Chem. Rec. 6(3) , 107-16, (2006) The chemistry of a novel zerovalent Ru complex, Ru(eta6-cot)(eta2-dmfm)2 (1) (cot=1,3,5-cyclooctatriene; dmfm=dimethyl fumarate), is reviewed with a focus on its reactivity toward phosphines, amines, and H2O, as well as arenes and p-quinones. A variety of nov... |
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Dimethyl fumarate - only an anti-psoriatic medication?
J. Dtsch. Dermatol. Ges. 10(11) , 793-801, (2012) Fumaric acid esters have been used successfully in the therapy of psoriasis vulgaris since 1959. In the last 17 years, many of the underlying mechanisms of anti-psoriatic action, such as a Th1/Th2 shift, a suppression of important leukocyte adhesion molecules... |