4-Bromo-2-nitrophenol

4-Bromo-2-nitrophenol Structure
4-Bromo-2-nitrophenol structure
Common Name 4-Bromo-2-nitrophenol
CAS Number 7693-52-9 Molecular Weight 218.005
Density 1.9±0.1 g/cm3 Boiling Point 259.4±20.0 °C at 760 mmHg
Molecular Formula C6H4BrNO3 Melting Point 90-94 °C(lit.)
MSDS Chinese USA Flash Point 110.7±21.8 °C
Symbol GHS07
GHS07
Signal Word Warning

FXR agonist activity of conformationally constrained analogs of GW 4064.

Bioorg. Med. Chem. Lett. 19(16) , 4733-9, (2009)

Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2g.