Eupatorin
Eupatorin structure
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Common Name | Eupatorin | ||
|---|---|---|---|---|
| CAS Number | 855-96-9 | Molecular Weight | 344.315 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 587.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H16O7 | Melting Point | 194-196°C | |
| MSDS | Chinese USA | Flash Point | 216.0±23.6 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control.
J. Agric. Food Chem. 47(11) , 4579-82, (1999) A reversed-phase HPLC procedure is proposed for the determination of seven flavonoids (luteolin, nepetin, hispidulin, jaceosidin, cirsimaritin, cirsilineol, and eupatorin) in vervain samples. A simple extractive technique was developed, involving only extract... |
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Flavones and rosmarinic acid from Salvia limbata.
Nat. Prod. Res. 24(20) , 1902-6, (2010) The genus Salvia (Lamiaceae) contains more than 50 shrub species in Iran, and Salvia limbata C.A. Meyer grows widely in the north and central parts of the country. Six flavones and rosmarinic acid were isolated from the ethyl acetate and methanol extracts of ... |
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Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation.
Planta Med. 78(8) , 779-86, (2012) Cytokines and other inflammatory mediators, such as prostaglandin E₂ (PGE₂) and nitric oxide (NO) produced by cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, activate and drive inflammation and therefore serve as targets for... |
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A simple isocratic HPLC method for the simultaneous determination of sinensetin, eupatorin, and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in Orthosiphon stamineus extracts.
J. Acupunct. Meridian Stud. 5(4) , 176-82, (2012) Orthosiphon stamineus extracts contain three flavonoids (3'-hydroxy-5,6,7,4'-tetramethoxyflavone, sinensetin, and eupatorin) as bioactive substances. Previous reported high performance liquid chromatography- ultraviolet (HPLC-UV) methods for the determination... |
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In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19).
J. Ethnopharmacol. 133(2) , 881-7, (2011) Andrographis paniculata (AP), Centella asiatica (CA) and Orthosiphon stamineus (OS) are three popular herbs traditionally used worldwide. AP is known for the treatment of infections and diabetes and CA is good for wound healing and healthy skin while OS is us... |
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The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
J. Nat. Prod. 72 , 1390-4, (2009) Flavonoids have often been associated with cancer prevention and activity of the human cytochrome P450 enzymes CYP1A1 and CYP1B1 with the occurrence of cancer. The flavones eupatorin (1) and cirsiliol (2) enhanced CYP1 enzyme activity in a concentration-depen... |
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Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase.
Prostaglandins Leukot. Essent. Fatty Acids 54(4) , 239-46, (1996) 15-Lipoxygenase from soybeans is inactivated by bubbling air through enzyme solutions. This inactivation is prevented by flavonoids from the East Asian medicinal plant Orthosiphon spicatus, previously found to be inhibitors of the enzyme. 5,7,4'-Trimethylapig... |
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The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.
Exp. Cell Res. 318(5) , 578-92, (2012) The spindle assembly checkpoint (SAC) is a conserved mechanism that ensures the fidelity of chromosome distribution in mitosis by preventing anaphase onset until the correct bipolar microtubule-kinetochore attachments are formed. Errors in SAC function may co... |
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Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves.
Fitoterapia 83(6) , 1000-7, (2012) Flavone eupatorin is one of the constituents of Orthosiphon stamineus, a medicinal herb used in folk medicine in South East Asia for treatment of various disorders. In our study, we investigated the antiproliferative properties of a chloroform extract of the ... |
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Determination of flavonoids from Orthosiphon stamineus in plasma using a simple HPLC method with ultraviolet detection.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 816(1-2) , 161-6, (2005) A simple liquid chromatographic method was developed for the simultaneous determination of flavonoids from Orthosiphon stamineus Benth, namely sinensitin, eupatorin and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone, in plasma. Prior to analysis, the flavonoids and ... |