Sodium cyanoborohydride
Sodium cyanoborohydride structure
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Common Name | Sodium cyanoborohydride | ||
|---|---|---|---|---|
| CAS Number | 25895-60-7 | Molecular Weight | 62.842 | |
| Density | 1.083 g/mL at 25 °C | Boiling Point | 307°C | |
| Molecular Formula | CH2BNNa | Melting Point | >242 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | −1 °F | |
| Symbol |
GHS02, GHS05, GHS06, GHS09 |
Signal Word | Danger | |
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The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014) SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that modulate SIRT6 activity could be of great therapeutic impo... |
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Fiber-optic immunosensor for detection of Crimean-Congo hemorrhagic fever IgG antibodies in patients.
Anal. Chem. 87 , 8394-8, (2015) Crimean-Congo hemorrhagic fever (CCHF) is a severe viral disease with high fatality rate. CCHF virus is endemic in parts of Africa, Asia, the Middle East, and southeastern Europe. Rapid diagnostics of CCHF is vital for appropriate clinical management and prev... |
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SPECHT - single-stage phosphopeptide enrichment and stable-isotope chemical tagging: quantitative phosphoproteomics of insulin action in muscle.
J. Proteomics 114 , 48-60, (2015) The study of cellular signaling remains a significant challenge for translational and clinical research. In particular, robust and accurate methods for quantitative phosphoproteomics in tissues and tumors represent significant hurdles for such efforts. In the... |
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Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics.
MAbs 7 , 881-90, (2015) Regulatory agencies have recently recommended a Quality by Design (QbD) approach for the manufacturing of therapeutic molecules. A QbD strategy requires deep understanding at the molecular level of the attributes that are crucial for safety and efficacy and f... |
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Unfolding and aggregation of a glycosylated monoclonal antibody on a cation exchange column. Part II. Protein structure effects by hydrogen deuterium exchange mass spectrometry.
J. Chromatogr. A. 1356 , 129-37, (2014) Hydrogen-deuterium exchange mass spectrometry (HX-MS) with proteolytic fragmentation is used to determine patterns of unfolding, as measured by increased solvent exposure, with peptide-level resolution for a glycosylated monoclonal antibody both when eluted f... |
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Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic.
Biomaterials 54 , 72-86, (2015) Recently, chemotherapy has been one of the most important therapeutic approaches for malignant tumors. The tumor tissular or intracellular microenvironment-sensitive polymer-doxorubicin (DOX) conjugates demonstrate great potential for improved antitumor effic... |
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Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles--part 1: separation-based methods.
MAbs 7(1) , 167-79, (2015) Immunoglobulin G (IgG) crystallizable fragment (Fc) glycosylation is crucial for antibody effector functions, such as antibody-dependent cell-mediated cytotoxicity, and for their pharmacokinetic and pharmacodynamics behavior. To monitor the Fc-glycosylation i... |
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Synthesis and application of boronic acid-functionalized magnetic adsorbent for sensitive analysis of salbutamol residues in pig tissues.
Biomed. Chromatogr. 29 , 1834-41, (2015) Salbutamol (SAL) is the most widely used β2 -agonist drug for asthma and chronic obstructive pulmonary patients, but it is also often abused as feed additive. In recent years, the abuse of SAL has led to a large number of food safety incidents. Therefore, the... |
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Chiral separation of D/L-aldoses by micellar electrokinetic chromatography using a chiral derivatization reagent and a phenylboronic acid complex.
Anal. Bioanal. Chem 407 , 6201-6, (2015) A novel method was developed for D/L-isomeric separation of aldopentoses and aldohexoses as their (S)-(+)-4-(N,N-dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole derivatives using phenylboronate buffer containing sodium dodecyl sulfate a... |
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Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function.
PLoS ONE 10 , e0128881, (2015) Increased blood glucose concentrations promote reactions between glucose and proteins to form advanced glycation end-products (AGE). Circulating AGE in the blood plasma can activate the receptor for advanced end-products (RAGE), which is present on both endot... |