2-Hydroxypropyl methacrylate
2-Hydroxypropyl methacrylate structure
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Common Name | 2-Hydroxypropyl methacrylate | ||
|---|---|---|---|---|
| CAS Number | 27813-02-1 | Molecular Weight | 144.168 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 218.8±23.0 °C at 760 mmHg | |
| Molecular Formula | C7H12O3 | Melting Point | -58°C | |
| MSDS | Chinese USA | Flash Point | 86.9±15.4 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Amphiphilic HPMA-LMA copolymers increase the transport of Rhodamine 123 across a BBB model without harming its barrier integrity.
J. Control. Release 163(2) , 170-7, (2012) The successful non-invasive treatment of diseases associated with the central nervous system (CNS) is generally limited by poor brain permeability of various developed drugs. The blood-brain barrier (BBB) prevents the passage of therapeutics to their site of ... |
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Aggregation behavior of amphiphilic p(HPMA)-co-p(LMA) copolymers studied by FCS and EPR spectroscopy.
Biomacromolecules 13(12) , 4065-74, (2012) A combined study of fluorescence correlation spectroscopy and electron paramagnetic resonance spectroscopy gave a unique picture of p(HPMA)-co-p(LMA) copolymers in aqueous solutions, ranging from the size of micelles and aggregates to the composition of the i... |
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Efficiency of high molecular weight backbone degradable HPMA copolymer-prostaglandin E1 conjugate in promotion of bone formation in ovariectomized rats.
Biomaterials 34(27) , 6528-38, (2013) Multiblock, high molecular weight, linear, backbone degradable HPMA copolymer-prostaglandin E1 (PGE1) conjugate has been synthesized by RAFT polymerization mediated by a new bifunctional chain transfer agent (CTA), which contains an enzymatically degradable o... |
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P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency.
J. Control. Release 163(1) , 63-74, (2012) In order to explore the influence of polymer microstructure and stereochemistry in biological settings, the synthesis, micellization, cellular fate and the use in paclitaxel formulations of poly(N-(2-hydroxypropyl)-methacrylamide)-block-poly(L-lactide) (P(HPM... |
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Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates.
Biomacromolecules 13(3) , 727-35, (2012) High-molecular-weight, branched N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesized and conjugated with Fab' fragments of the anti-CD20 antibody, 1F5. This produced multivalent conjugates with varying valency (amount of Fab' per macromolecule... |
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Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis.
Biomaterials 33(29) , 7174-81, (2012) A hybrid biomimetic system comprising high-molecular-weight, linear copolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) grafted with multiple Fab' fragments of anti-CD20 monoclonal antibody (mAb) was synthesized by reversible addition-fragmentation chain tr... |
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Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging.
Biomacromolecules 13(3) , 652-63, (2012) Preclinical in vivo characterization of new polymeric drug conjugate candidates is crucial for understanding the effects of certain chemical modifications on distribution and elimination of these carrier systems, which is the basis for rational drug design. I... |
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Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting.
Eur. J. Pharm. Sci. 42(5) , 527-39, (2011) New biodegradable star polymer-doxorubicin (Dox) conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core ... |
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HPMA copolymers as surfactants in the preparation of biocompatible nanoparticles for biomedical application.
Biomacromolecules 13(12) , 4179-87, (2012) In this work we describe the application of amphiphilic N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers as polymeric surfactants in miniemulsion techniques. HPMA-based copolymers with different ratios of HPMA (hydrophilic) to laurylmethacrylate (LMA... |
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HPMA based amphiphilic copolymers mediate central nervous effects of domperidone.
Macromol. Rapid Commun. 32(9-10) , 712-7, (2011) In this study we give evidence that domperidone encapsulated into amphiphilic p(HPMA)-co-p(laurylmethacrylate) (LMA) copolymer aggregates is able to cross the blood-brain barrier, since it affected motor behaviour in animals, which is a sensitive measure for ... |