Pheophorbide A
Pheophorbide A structure
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Common Name | Pheophorbide A | ||
|---|---|---|---|---|
| CAS Number | 15664-29-6 | Molecular Weight | 592.68 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1019.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C35H36N4O5 | Melting Point | 191-195°C (lit.) | |
| MSDS | Chinese USA | Flash Point | 570.1±34.3 °C | |
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Antioxidant-photosensitizer dual-loaded polymeric micelles with controllable production of reactive oxygen species.
Int. J. Pharm. 471(1-2) , 339-48, (2014) Poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL) micelles dually loaded with both pheophorbide a (PhA) as a photosensitizer and β-carotene (CAR) as a singlet oxygen ((1)O2) scavenger were designed to control photodynamic therapy (PDT) activity in cancer... |
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In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.
J. Pharm. Pharmacol. 67(2) , 170-7, (2015) It has been reported that intestinal urate excretion is increased at chronic kidney disease (CKD) state. In this report, whether uremic toxins are involved in the upregulation of intestinal breast cancer resistance protein (BCRP), an intestinal urate exporter... |
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ABCG2 transporter inhibitor restores the sensitivity of triple negative breast cancer cells to aminolevulinic acid-mediated photodynamic therapy.
Sci. Rep. 5 , 13298, (2015) Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodynamic therapy (PDT) were analyzed in MCF10A normal breast epithelial cells and a panel of human breast cancer cells including estrogen receptor (ER) ... |
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Polyelectrolyte nanocomplex formation of heparin-photosensitizer conjugate with polymeric scavenger for photodynamic therapy.
Carbohydr. Polym. 121 , 122-31, (2015) A polyelectrolyte nanocomplex was prepared via the ionic interaction between the anionic heparin-pheophorbide a (HPhA) conjugate, which served as a water-soluble polysaccharide photosensitizer (PS), and the cationic polyethylenimine (PEI)-β-carotene (PCAR) co... |
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Pheophorbide a-mediated photodynamic therapy induces autophagy and apoptosis via the activation of MAPKs in human skin cancer cells.
Oncol. Rep. 31(1) , 137-44, (2014) Pheophorbide a (Pa), a chlorophyll derivative, is a photosensitizer that can induce significant antitumor effects in several types of tumor cells. The present study investigated the mechanism of Pa-mediated photodynamic therapy (Pa-PDT) in the human skin canc... |
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Photodynamic therapy induced cell death of hormone insensitive prostate cancer PC-3 cells with autophagic characteristics.
Photodiagnosis Photodyn. Ther. 10(3) , 278-87, (2013) The introduction of photodynamic therapy (PDT) to the treatment of advanced prostate cancer can accomplish the eradication of local neoplasm and distant metastases with minimized damage to the adjacent structures. The evidence of PDT efficacy for androgen-ref... |
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Determination of the concentration of potential efflux pump inhibitors, pheophorbide a and pyropheophorbide a, in the feces of animals by fluorescence spectroscopy.
J. Agric. Food Chem. 60(42) , 10456-60, (2012) Efflux pumps are vital bacterial components, and research has demonstrated that some plant compounds such as pheophorbide a (php) possess efflux pump inhibitor (EPI) activity. This study determined the quantity of php present in feces as an indicator of EPI a... |
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Transcriptomics and physiological analyses reveal co-ordinated alteration of metabolic pathways in Jatropha curcas drought tolerance.
J. Exp. Bot. 67 , 845-60, (2016) Jatropha curcas, a multipurpose plant attracting a great deal of attention due to its high oil content and quality for biofuel, is recognized as a drought-tolerant species. However, this drought tolerance is still poorly characterized. This study aims to cont... |
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Enhanced efficacy of photodynamic therapy by inhibiting ABCG2 in colon cancers.
BMC Cancer 15 , 504, (2015) Photodynamic therapy (PDT) contains a photosensitizing process, which includes cellular uptake of photosensitizer and delivery of light to the target. ATP-binding cassette subfamily G2 (ABCG2) regulates endogenous protoporphyrin levels. In human colon cancers... |