19-Norethindrone acetate
19-Norethindrone acetate structure
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Common Name | 19-Norethindrone acetate | ||
|---|---|---|---|---|
| CAS Number | 51-98-9 | Molecular Weight | 340.456 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 454.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C22H28O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 197.1±28.8 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Toxicol. Mech. Methods 18 , 217-27, (2008) ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the dev... |
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Molecular modulation of estrogen-induced apoptosis by synthetic progestins in hormone replacement therapy: an insight into the women's health initiative study.
Cancer Res. 74(23) , 7060-8, (2014) Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alo... |
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Norethisterone acetate alters coagulation gene expression in vitro in human cell culture.
Thromb. Res. 131(1) , 72-7, (2013) Both oestrogen and progestin and the route of administration have been implicated in cardiovascular and thromboembolic risk in post menopausal hormone users. Transdermal preparations have been reported as safer indicating that liver derived metabolites of oes... |
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Comparison of cervical mucus of 24/4 vs. 21/7 combined oral contraceptives.
Contraception 86(6) , 710-5, (2012) Few studies have examined the action of combined oral contraceptives (COCs) on cervical mucus. We hypothesized that midcycle cervical mucus of women taking COCs is of poor quality when compared to their own midcycle mucus prior to initiating COCs. We sought t... |
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The hormonal profile of norethindrone acetate: rationale for add-back therapy with gonadotropin-releasing hormone agonists in women with endometriosis.
Reprod. Sci. 19(6) , 563-71, (2012) Gonadotropin-releasing hormone agonists (GnRHa) are an effective treatment of endometriosis-associated pelvic pain. The use of hormonal add-back therapy can alleviate the hypoestrogenic symptoms associated with GnRHa therapy, while preserving therapeutic effi... |
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Effects of a continuous-combined regimen of low-dose hormone therapy (oestradiol and norethindrone acetate) and tibolone on the quality of life in symptomatic postmenopausal women: a double-blind, randomised study.
Maturitas 74(2) , 172-8, (2013) This study compared the effects of a continuous-combined regimen of low-dose hormone therapy (LD-HT) versus tibolone and supplemental calcium/vitamin D3 (control) on quality of life (QoL) in symptomatic postmenopausal women.This study was a prospective, rando... |
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Changes in the size of rectovaginal endometriotic nodules infiltrating the rectum during hormonal therapies.
Arch. Gynecol. Obstet. 287(3) , 447-53, (2013) To evaluate the changes in the volume of rectovaginal endometriotic nodules infiltrating the rectum during 12-month treatment with hormonal therapies.This prospective, non-randomized, self-controlled clinical trial included patients with rectovaginal endometr... |
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Norethisterone and norethisterone acetate.
IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 21 , 441-60, (1979)
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Ovarian cancer risk in postmenopausal women using estradiol-progestin therapy - a nationwide study.
Climacteric 16(1) , 48-53, (2013) While previous data link the use of postmenopausal hormone therapy to an increased risk for ovarian cancer, little is known about the impact of various progestins, modes or routes of administration of hormone therapy for this risk. In this nationwide study, w... |