Oxipurinol
Oxipurinol structure
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Common Name | Oxipurinol | ||
|---|---|---|---|---|
| CAS Number | 2465-59-0 | Molecular Weight | 152.11 | |
| Density | 2.19g/cm3 | Boiling Point | 662.9ºC at 760 mmHg | |
| Molecular Formula | C5H4N4O2 | Melting Point | 300 °C | |
| MSDS | Chinese USA | Flash Point | 354.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Evaluation of neuronal protective effects of xanthine oxidoreductase inhibitors on severe whole-brain ischemia in mouse model and analysis of xanthine oxidoreductase activity in the mouse brain.
Neurol. Med. Chir. (Tokyo) 55(1) , 77-85, (2015) Global cerebral ischemia and reperfusion (I/R) often result in high mortality. Free radicals play an important role in global cerebral I/R. Xanthine oxidoreductase (XOR) inhibitors, such as allopurinol, have been reported to protect tissues from damage caused... |
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Systematic and Molecular Basis of the Antibacterial Action of Quinoxaline 1,4-Di-N-Oxides against Escherichia coli.
PLoS ONE 10 , e0136450, (2015) Quinoxaline 1,4-di-N-oxides (QdNOs) are widely known as potent antibacterial agents, but their antibacterial mechanisms are incompletely understood. In this study, the transcriptomic and proteomic profiles of Escherichia coli exposed to QdNOs were integrative... |
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Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation.
Biochemistry 53(22) , 3679-88, (2014) Ischemia-reperfusion injury is accompanied by endothelial hypoxia and reoxygenation that trigger oxidative stress with enhanced superoxide generation and diminished nitric oxide (NO) production leading to endothelial dysfunction. Oxidative depletion of the en... |
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Oxypurinol, allopurinol and allopurinol-1-riboside in plasma following an acute overdose of allopurinol in a patient with advanced chronic kidney disease.
Br. J. Clin. Pharmacol. 73(5) , 828-9, (2012)
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Regulation of high glucose-mediated mucin expression by matrix metalloproteinase-9 in human airway epithelial cells.
Exp. Cell Res. 333(1) , 127-35, (2015) Mucus hypersecretion is the key manifestation in patients with chronic inflammatory airway diseases and mucin 5AC (MUC5AC) is a major component of airway mucus. Matrix metalloproteinases (MMP)-9, have been found to be involved in the pathogenesis of inflammat... |
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Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin.
Toxicol. Sci. 145 , 59-67, (2015) Docetaxel (DTX), a taxane drug, has widely been used as an anticancer or antiangiogenesis drug. However, DTX caused side effects, such as vessel damage and phlebitis, which may reduce its clinical therapeutic efficacy. The molecular mechanisms of DTX that cau... |
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HZE ⁵⁶Fe-ion irradiation induces endothelial dysfunction in rat aorta: role of xanthine oxidase.
Radiat. Res. 176(4) , 474-85, (2011) Ionizing radiation has been implicated in the development of significant cardiovascular complications. Since radiation exposure is associated with space exploration, astronauts are potentially at increased risk of accelerated cardiovascular disease. This stud... |
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Modelling the reduced xanthine oxidase in active sulfo and inactive desulfo forms.
Dalton Trans. 42(9) , 3050-8, (2013) Synthesis of two complexes, [NBu(n)(4)][Mo(IV)O(mnt)(S-Tol)(N-N)] (N-N = 2,2'-bipyridine (1a) or 1,10-phenanthroline (1b); mnt = maleonitriledithiolate; S-Tol = toluenethiol) are reported. These on treatment with H(2)S generate the corresponding [NBu(n)(4)][M... |
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Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis.
Clin. Sci. 123(8) , 509-18, (2012) Oestrogen protects cardiovascular health partially via an up-regulation of NO• (NO radical) production. Its synthetic analogue DES (diethylstilbestrol), used as a potent androgen deprivation therapy for patients with prostate cancer, is however associated wit... |