SC 19220
SC 19220 structure
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Common Name | SC 19220 | ||
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| CAS Number | 19395-87-0 | Molecular Weight | 331.754 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C16H14ClN3O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats.
Cardiovasc. Res. 78(1) , 130-8, (2008) The present study examined the hypothesis that prostaglandin E2 (PGE2) through activation of prostaglandin E (EP) receptor contributes to endothelium-dependent contractions.Western blotting revealed that the protein expression of EP1 receptor was significantl... |
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Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.
PLoS ONE 7(9) , e45273, (2012) Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investigated in detail. In our experiments, prostaglandin (PG)F(2α)... |
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Prostaglandin E₂ possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.
Prostaglandins Leukot. Essent. Fatty Acids 106 , 11-Aug, (2016) We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) in COPD subjects. Lung fibroblasts from Contr... |
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The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.
J. Cell Sci. 116(Pt 16) , 3285-94, (2003) Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells by activation of vasopressin V2 receptors and the subsequent translocation of water channels (aquaporin-2, AQP2) from intracellular vesicles into the plasma mem... |
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Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane.
Prostaglandins Leukot. Essent. Fatty Acids 87(2-3) , 79-89, (2012) The chick chorioallantoic membrane (CAM) subserves gas exchange in the developing embryo and shell-less culture affords a unique opportunity for direct observations over time of individual blood vessels to pharmacologic interventions. We tested a number of li... |
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Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
Osteoarthr. Cartil. 12(11) , 895-903, (2004) Calpains are known as Ca(2+)-dependent intracellular neutral cysteine proteases. However, m-calpain is detected in synovial fluid of arthritic joints and is shown to possess the proteoglycanase activity in vitro. The mechanism of m-calpain release into the ex... |
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Prostaglandin regulation of gastric slow waves and peristalsis.
Am. J. Physiol. Gastrointest. Liver Physiol. 296(6) , G1180-90, (2009) Gastric emptying depends on functional coupling of slow waves between the corpus and antrum, to allow slow waves initiated in the gastric corpus to propagate to the pyloric sphincter and generate gastric peristalsis. Functional coupling depends on a frequency... |
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PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1beta-induced fever in rats.
Am. J. Physiol. 275(6 Pt 2) , R1762-5, (1998) We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central injection of interl... |
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SC-19220, antagonist of prostaglandin E2 receptor EP1, inhibits osteoclastogenesis by RANKL.
J. Bone Miner Res. 20(1) , 15-22, (2005) We examined the direct effect of SC-19220, an EP1 prostaglandin (PG) E2 receptor antagonist, on osteoclastogenesis induced by RANK/RANKL signaling in mouse cell cultures. We found that SC-19220 inhibited RANKL-induced osteoclastogenesis by suppression of the ... |
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Prostaglandin moieties that determine receptor binding specificity in the bovine corpus luteum.
J. Reprod. Fertil. 116(1) , 133-41, (1999) This study provided a pharmacological evaluation of prostaglandin binding to bovine luteal plasma membrane. It was found that [3H]PGF2 alpha' [3H]PGE2' [3H]PGE1 and [3H]PGD2 all bound with high affinity to luteal plasma membrane but had different specificitie... |