Go 6983
Go 6983 structure
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Common Name | Go 6983 | ||
|---|---|---|---|---|
| CAS Number | 133053-19-7 | Molecular Weight | 442.510 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 709.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C26H26N4O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 382.6±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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HSPB1 as a novel regulator of ferroptotic cancer cell death.
Oncogene 34(45) , 5617-25, (2015) Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. Erastin, a specific f... |
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High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation.
Integr. Biol. (Camb.) 7 , 513-24, (2015) As key components of autocrine signaling, pericellular proteases, a disintegrin and metalloproteinases (ADAMs) in particular, are known to impact the microenvironment of individual cells and have significant implications in various pathological situations inc... |
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Downregulation of vimentin in macrophages infected with live Mycobacterium tuberculosis is mediated by Reactive Oxygen Species.
Sci. Rep. 6 , 21526, (2016) Mycobacterium tuberculosis persists primarily in macrophages after infection and manipulates the host defence pathways in its favour. 2D gel electrophoresis results showed that vimentin, an intermediate filament protein, is downregulated in macrophages infect... |
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Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia.
PLoS ONE 10 , e0145522, (2015) The relationship between chronic inflammation and cancer is well known. The inflammation increases the permeability of blood vessels and consequently elevates pressure in the interstitial tissues. However, there have been only a few reports on the effects of ... |
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Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect.
J. Thorac. Cardiovasc. Surg. 285 , 4883-95, (2010) Expression of the VACM-1/cul5 gene in endothelial and in cancer cell lines in vitro inhibits cellular proliferation and decreases phosphorylation of MAPK. Structure-function analysis of the VACM-1 protein sequence identified consensus sites specific for phosp... |
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Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance.
Stem Cells 29 , 618-28, (2011) The intricate molecular mechanisms that regulate ESC pluripotency are incompletely understood. Prior research indicated that activation of the Janus kinase-signal transducer and activator of transcription (STAT3) pathway or inhibition of extracellular signal-... |
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Derivation of novel human ground state naive pluripotent stem cells.
Nature 504(7479) , 282-6, (2013) Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhi... |
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Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.
J. Biol. Chem. 290 , 21845-56, (2015) Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibi... |