SC-236
SC-236 structure
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Common Name | SC-236 | ||
|---|---|---|---|---|
| CAS Number | 170569-86-5 | Molecular Weight | 401.791 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 543.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C16H11ClF3N3O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 282.4±32.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration.
Biol. Chem. 396 , 803-12, (2015) Sphingosine 1-phosphate (S1P) is generated by sphingosine kinase (SK)-1 and -2 and acts mainly as an extracellular ligand at five specific receptors, denoted S1P1-5. After activation, S1P receptors regulate important processes in the progression of renal dise... |
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Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice.
Am. J. Physiol. Renal Physiol. 309 , F332-40, (2015) Thromboxane (Tx) A2 has been suggested to be involved in the development of sepsis-induced acute kidney injury (AKI). Therefore, we investigated the impact of cyclooxygenase (COX)-1 and COX-2 activity on lipopolysaccharide (LPS)-induced renal TxA2 formation, ... |
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COX-2 gene dosage-dependent defects in kidney development.
Am. J. Physiol. Renal Physiol. 310 , F1113-22, (2016) Deletion of cyclooxygenase (COX)-2 causes impairment of kidney development, including hypothrophic glomeruli and cortical thinning. A critical role for COX-2 is seen 4-8 days postnatally. The present study was aimed at answering whether different COX-2 gene d... |