Nisoldipine
Nisoldipine structure
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Common Name | Nisoldipine | ||
|---|---|---|---|---|
| CAS Number | 63675-72-9 | Molecular Weight | 388.414 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 505.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H24N2O6 | Melting Point | 147-148°C | |
| MSDS | Chinese USA | Flash Point | 259.7±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Fast disintegrating tablets of nisoldipine for intra-oral administration.
Pharm. Dev. Technol. 19(6) , 641-50, (2014) Nisoldipine is a calcium channel blocker with low and variable oral bioavailability. This was attributed to slow dissolution and presystemic metabolism. Accordingly, the objective of this work was to enhance the dissolution rate of nisoldipine to formulate fa... |
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Anti-arrhythmic and hemodynamic effects of oxy nifedipine, oxy nimodipine, oxy nitrendipine and oxy nisoldipine.
Pharmacol. Res. 66(4) , 300-8, (2012) Our previous studies have established cardio-protective effects of furnidipine and its active metabolites. We therefore decided to compare the influence of oral and intravenous administration of furnidipine, nifedipine, nitrendipine and nimodipine to examine ... |
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Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?
Am. J. Cardiol. 75(13) , 36E-40E, (1995) Nisoldipine is a dihydropyridine calcium entry blocker that inhibits contraction of vascular smooth muscle with a potency that is 2-3 times greater than its impact on myocardial contractility. In isolated human coronary arteries, tonic contractions induced by... |
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Simultaneous determination ofm-nisoldipine and its three metabolites in rat plasma by liquid chromatography–mass spectrometry
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(29) , 2989-96, (2010) A simple, sensitive and selective liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the simultaneous determination of m-nisoldipine and its three metabolites in rat plasma has been developed using nitrendipine as an internal standard (IS). ... |
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Adenoviral-mediated expression of dihydropyridine-insensitive L-type calcium channels in cardiac ventricular myocytes and fibroblasts.
Eur. J. Pharmacol. 565(1-3) , 7-16, (2007) Cardiac voltage-gated Ca2+ channels regulate the intracellular Ca2+ concentration and are therefore essential for muscle contraction, second messenger activation, gene expression and electrical signaling. As a first step in accessing the structural versus fun... |
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Nisoldipine: a new dihydropyridine calcium-channel blocker.
J. Clin. Pharmacol. 33(1) , 46-52, (1993) Nisoldipine is a new calcium-channel blocker of the dihydropyridine subclass, with a chemical structure similar to nifedipine. It has been used in clinical trials to assess its efficacy and safety in patients with hypertension, angina pectoris, and congestive... |
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Influence of cilnidipine or nisoldipine on sympathetic activity in healthy male subjects.
Heart Vessels 22(6) , 404-9, (2007) The aim of this study was to investigate whether cilnidipine, an N- and L-type calcium channel blocker, and nisoldipine, an L-type calcium channel blocker, have different effects on sympathetic activity, using an identical group of healthy male subjects. Eigh... |
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Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes.
J. Membr. Biol. 235(2) , 73-87, (2010) HL-1 is the adult murine cardiac cell line that can be passaged repeatedly in vitro without losing differentiated phenotype. The present study was designed to characterize the rapidly activating delayed rectifier potassium current, I (Kr), endogenously expres... |
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Nisoldipine CC: clinical experience in hypertension.
Cardiology 88 Suppl 1 , 56-62; discussion 63-5, (1997) Nisoldipine coat core (CC) is a long-acting formulation of the dihydropyridine calcium channel blocker nisoldipine, suitable for once-daily administration in the treatment of patients with hypertension. Data are reported from three randomized, controlled tria... |
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Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes.
Eur. J. Pharmacol. 598 , 94-98, (2008) The non-selective muscarinic receptor antagonist propiverine impairs L-type Ca(2+) currents (I(Ca,L)) in human detrusor smooth muscle cells and atrial cardiomyocytes. Here, we have investigated the effects of three metabolites of propiverine on human cardiac ... |