Methyl thioglycolate

Methyl thioglycolate Structure
Methyl thioglycolate structure
Common Name Methyl thioglycolate
CAS Number 2365-48-2 Molecular Weight 106.144
Density 1.1±0.1 g/cm3 Boiling Point 151.9±0.0 °C at 760 mmHg
Molecular Formula C3H6O2S Melting Point -24 °C
MSDS Chinese USA Flash Point 35.0±7.8 °C
Symbol GHS02 GHS06
GHS02, GHS06
Signal Word Danger

Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging.

Small 10(24) , 5137-50, (2014)

The blood-brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Here, a transactivator of transcription (TAT) peptide-modified gold nanoparticle platform...

Ligand-controlled growth of ZnSe quantum dots in water during Ostwald ripening.

Langmuir 28(36) , 12931-40, (2012)

A strong ligand effect was observed for the aqueous-phase growth of ZnSe quantum dots (QDs) in the Ostwald ripening (OR) stage. The QDs were made by injecting Se monomer at room temperature followed by a ramp to 100 °C. The ramp produced a second, more gradua...

Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography/mass spectrometry.

Rapid Commun. Mass Spectrom. 13(5) , 350-3, (1999)

A gas chromatography/mass spectrometry (GC/MS) method has been developed to determine two methylated arsenic species in human urine samples. The yield of derivatization for dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) using thioglycol methylate...

Thermochromism of heme adducts of Glycera hemoglobin and some other monomeric heme proteins.

J. Inorg. Biochem. 39(4) , 351-69, (1990)

The thermally induced difference spectra of myoglobin (Mb) and Glycera dibranchiata hemoglobin (Hbm) derivatives and of cytochrome-c were recorded between 4 degrees and 30 degrees C in the 390-750 nm range. Thermodynamic parameters were estimated and upper an...

Gold Nanorods Conjugated with Doxorubicin and cRGD for Combined Anticancer Drug Delivery and PET Imaging.

Theranostics 2(8) , 757-68, (2012)

A multifunctional gold nanorod (GNR)-based nanoplatform for targeted anticancer drug delivery and positron emission tomography (PET) imaging of tumors was developed and characterized. An anti-cancer drug (i.e., doxorubicin (DOX)) was covalently conjugated ont...

Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.

Bioorg. Med. Chem. Lett. 11(2) , 91-4, (2001)

Arylalkylidene rhodanines 2(a-d) inhibit HCV NS3 protease at moderate concentrations. They are better inhibitors of other serine proteases such as chymotrypsin and plasmin. However, the selectivity of arylmethyliden e rhodanines (8a, 9a) with bulkier and more...

Reductive and nucleophilic activation products of dynemicin A with methyl thioglycolate. A rational mechanism for DNA cleavage of the thiol-activated dynemicin A.

Biochemistry 30(12) , 2989-92, (1991)

The reaction products of methyl thioglycolate with dynemicin A, dynemicin H and dynemicin S, were isolated by HPLC purification and identified spectroscopically. The major product, dynemicin H (C30H23NO9), was determined to be a C-8 hydrogen analogue of dynem...

Sequence preference for strand cleavage of gapped duplexes by dynemicin A: possible mechanism of sequence-dependent double-stranded breaks.

Biochemistry 34(31) , 9944-50, (1995)

A double-stranded DNA cleavage mechanism by a novel enediyne type antitumor antibiotic, dynemicin A, has been investigated through sequence-dependent strand breakage of a series of duplexes containing a single nucleotide gap. We found that (1) dynemicin A bre...

Neocarzinostatin chromophore. Assignment of spectral properties and structural requirements for binding to DNA.

Mol. Pharmacol. 23(2) , 500-10, (1983)

The site responsible for the mercaptan (or borohydride)-stimulated DNA scission activity of neocarzinostatin chromophore (NCS-Chrom) is located in the central C12-subunit of the molecule. This has been determined by studies of the characteristic spectral prop...

DFT characterization of key intermediates in thiols oxidation catalyzed by amavadin.

Dalton Trans. 40(30) , 7704-12, (2011)

Amavadin is an unusual octa-coordinated V(IV) complex isolated from Amanita muscaria mushrooms. The outer-sphere catalytic properties of such a complex toward several oxidation reactions are well known. Nevertheless, a remarkable example exists, in which the ...