Acetohexamide
Acetohexamide structure
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Common Name | Acetohexamide | ||
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| CAS Number | 968-81-0 | Molecular Weight | 324.39500 | |
| Density | 1.3g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H20N2O4S | Melting Point | 188-190° (GB 912789); mp 175-177° (Marshall) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair.
Cancer Res. 74(21) , 6205-15, (2014) Cancers due to germline mutations in the BRCA1 gene tend to lack targets for approved chemoprevention agents. This study aimed at a targeted chemoprevention strategy for BRCA1-associated malignancies. Mutant BRCA1 limits the base-excision DNA repair activity ... |
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Analysis of free drug fractions by ultrafast affinity extraction: interactions of sulfonylurea drugs with normal or glycated human serum albumin.
J. Chromatogr. A. 1371 , 82-9, (2014) Ultrafast affinity extraction and a multi-dimensional affinity system were developed for measuring free drug fractions at therapeutic levels. This approach was used to compare the free fractions and global affinity constants of several sulfonylurea drugs in t... |
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CURRENT THERAPEUTICS. CCII. ACETOHEXAMIDE.
Practitioner 193 , 555-60, (1964)
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In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen.
Br. J. Cancer 108(3) , 570-8, (2013) As metastasis is the prime cause of death from malignancies, there is vibrant interest to discover options for the management of the different mechanistic steps of tumour spreading. Some approved pharmaceuticals exhibit activities against diseases they have n... |
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Catalytic properties of carbonyl reductase from rabbit liver for analogs of acetohexamide and 4-acetylpyridine.
Biochem. Mol. Biol. Int. 33(5) , 893-9, (1994) A correlation was observed between the values of specificity constant (kcat/Km) of carbonyl reductase from rabbit liver for acetohexamide analogs and their partition coefficients. This result indicates that the hydrophobicity in straight-chain alkyl groups of... |
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Cadmium exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity.
Arch. Toxicol. 76(1) , 8-12, (2002) Administration of cadmium (Cd) at a dose of 1.23 mg/kg (2.0 mg/kg as CdCl(2)) markedly decreased the activity of an enzyme (acetohexamide reductase) catalysing the ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of male rats.... |
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Crystallization of a new polymorph of acetohexamide from 2-hydroxybutyl-β-cyclodextrin solution: form VI with a high aqueous solubility.
Int. J. Pharm. 453(2) , 315-21, (2013) A new polymorph of acetohexamide (Form VI) was prepared via the formation of a complex with 2-hydoxybutyl-β-cyclodextrin (HB-β-CD) in aqueous solution. An alkaline solution of acetohexamide and HB-β-CD was adjusted to pH 4.0 by titration with hydrochloric aci... |
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Strain- and sex-related differences of carbonyl reductase activities in kidney microsomes and cytosol of rats.
J. Appl. Toxicol. 24(6) , 437-41, (2004) This study was designed to elucidate strain- and sex-related differences of carbonyl reductase activity in rat kidney by using the oral antidiabetic drug acetohexamide as substrate. The frequency distribution of carbonyl reductase activities in kidney microso... |
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Purification and catalytic properties of a novel acetohexamide-reducing enzyme from rabbit heart.
J. Biochem. 119(4) , 648-52, (1996) An enzyme catalyzing the metabolic reduction of acetohexamide [4-acetyl-N-(cyclohexyl-carbamoyl)benzenesulfonamide], an oral antidiabetic drug, was purified to homogeneity from the cytosolic fraction of rabbit heart. The molecular mass of the purified enzyme ... |
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Characterization of acetohexamide reductases purified from rabbit liver, kidney, and heart: structural requirements for substrates and inhibitors.
J. Biochem. 121(4) , 705-10, (1997) The structural requirements of acetohexamide reductases purified from rabbit liver, kidney, and heart for substrates and inhibitors were examined. Acetohexamide, an oral antidiabetic drug with a ketone group, and analogs of it with various alkyl groups instea... |