Denopamine
Denopamine structure
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Common Name | Denopamine | ||
|---|---|---|---|---|
| CAS Number | 71771-90-9 | Molecular Weight | 317.38 | |
| Density | 1.177g/cm3 | Boiling Point | 518.8ºC at 760 mmHg | |
| Molecular Formula | C18H23NO4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 267.6ºC | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.
Mol. Pharmacol. 56 , 875-885, (1999) We examined the subtype-selective binding site of the beta-adrenergic receptors (betaARs). The beta(1)/beta(2)-chimeric receptors showed the importance of the second and seventh transmembrane domains (TM2 and TM7) of the beta(2)AR for the binding of the beta(... |
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Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform.
Drug Metab. Dispos. 33(3) , 403-12, (2005) Denopamine is one of the oral beta(1)-adrenoceptor-selective partial agonists. Denopamine glucuronide is the most abundant metabolite in human, rat, and dog urine when administered orally. Species differences in denopamine glucuronidation were investigated wi... |
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Vascular responses to beta-adrenoceptor subtype-selective agonists with and without endothelium in rat common carotid arteries.
J. Auton. Pharmacol. 21(1) , 7-13, (2001) 1. Using the cannula inserting method, vasodilator responses to beta-adrenoceptor agonists (isoprenaline, denopamine and procaterol) were investigated in isolated and perfused rat common carotid arteries. 2. Each beta-adrenoceptor agonist induced a vasodilati... |
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Denopamine stimulates alveolar fluid clearance via cystic fibrosis transmembrane conductance regulator in rat lungs.
Respirology 11(5) , 566-71, (2006) The objective of this study was to test the hypothesis that cystic fibrosis transmembrane conductance regulator (CFTR) plays a role in beta(1)-adrenergic agonist-stimulated alveolar fluid clearance.Isotonic 5% albumin solutions containing different pharmacolo... |
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Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator.
Curr. Med. Res. Opin. 18(7) , 407-13, (2002) Up until now, it has been suggested that nitrate and/or calcium channel blockers were effective against variant angina pectoris. On the other hand, it is known that about 20% of variant angina pectoris was refractory to both nitrate and calcium channel blocke... |
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Modulation of L-type Ca current by denopamine, a nonparenteral partial beta 1 stimulant, in rabbit ventricular cells.
Naunyn Schmiedebergs Arch. Pharmacol. 354(4) , 437-43, (1996) The effects of denopamine, a nonparenteral partial beta agonist which is used clinically in Japan, on the L-type Ca2+ current (ICa) were examined in rabbit ventricular cells. Denopamine stimulated basal ICa with a maximum response of +33.2% and a concentratio... |
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ATP-sensitive K+ channel opener pinacidil augments beta 1-adrenoceptor-induced coronary vasodilation in dogs.
Am. J. Physiol. 270(6 Pt 2) , H2210-5, (1996) The opening of ATP-sensitive K+ (K+ATP) channels contributes to the mechanism of metabolic coronary vasodilation. The aim of the present study was to determine whether K+ATP channel opener pinacidil augments coronary vasodilation induced by beta-adrenoceptor ... |
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Selective beta2-adrenoceptor agonist enhances sensitivity to cisplatin in non-small cell lung cancer cell line.
Oncol. Rep. 7(1) , 49-52, (2000) Cisplatin is a key drug in chemotherapy for lung cancer. It has been reported that intracellular accumulation of cisplatin is an important step as a determinant for resistance to cisplatin, which may be modulated by Na+, K+-ATPase activity. And it has been re... |
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[Fast drug analysis by capillary electrophoresis. II. Analysis of denopamine tablets. Effects of purity of dimethyl beta-cyclodextrin as chiral selector on enantiomer separations].
Yakugaku Zasshi 119(4) , 288-98, (1999) Capillary electrophoresis (CE) has been utilized as a tool for enantiomeric separation. It has been incorporated into both USP and EP forums as the methods for general tests and assays. In the present study, we applied CE to the assay and content uniformity o... |
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Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment.
Int. J. Cardiol. 108(2) , 281-3, (2006)
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