Hyperforin dicyclohexylammonium salt

Hyperforin dicyclohexylammonium salt Structure
Hyperforin dicyclohexylammonium salt structure
Common Name Hyperforin dicyclohexylammonium salt
CAS Number 238074-03-8 Molecular Weight 718.10300
Density N/A Boiling Point N/A
Molecular Formula C47H75NO4 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy.

Mol. Cancer Ther. 10 , 336-46, (2011)

Oncogenic KRAS is found in more than 25% of lung adenocarcinomas, the major histologic subtype of non-small cell lung cancer (NSCLC), and is an important target for drug development. To this end, we generated four NSCLC lines with stable knockdown selective f...

Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.

Clin. Cancer Res. 15 , 6852-61, (2009)

Signal transducer and activator of transcription-3 (STAT3) is downstream of growth factor and cytokine receptors, and regulates key oncogenic pathways in non-small cell lung cancer (NSCLC). Activation of STAT3 by cellular Src (c-Src) promotes tumor progressio...

Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a.

Cancer Res. 70 , 9185-96, (2010)

Increasing evidence points to the functional importance of alternative splice variations in cancer pathophysiology. Two splice variants are derived from the CASP9 gene via the inclusion (Casp9a) or exclusion (Casp9b) of a four-exon cassette. Here we show that...

Prostaglandin E2 stimulates human lung carcinoma cell growth through induction of integrin-linked kinase: the involvement of EP4 and Sp1.

Cancer Res. 69 , 896-904, (2009)

Cyclooxygenase-2-derived prostaglandin E(2) (PGE(2)) stimulates tumor cell growth and progression. However, the mechanisms by which PGE(2) increases tumor growth remain incompletely understood. In studies performed in non-small cell lung carcinoma (NSCLC) cel...

Lipid raft modulation inhibits NSCLC cell migration through delocalization of the focal adhesion complex.

Lung Cancer 69 , 165-71, (2010)

Lipid raft, a specialized membrane structure enriched with cholesterol and glycosphingolipid, contains molecules that convey environmental stimuli to the intracellular systems. Authors investigated the effects of raft cholesterol depletion on non-small cell l...

Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction.

J. Physiol. 588 , 1361-8, (2010)

The attenuated reflex vasoconstriction in aged skin may be partly mediated by oxidant-induced reduction in functional substrate and cofactor availability for noradrenaline biosynthesis. We hypothesized that localized supplementation of tyrosine and tetrahydro...