Tetramethylthiourea
Tetramethylthiourea structure
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Common Name | Tetramethylthiourea | ||
|---|---|---|---|---|
| CAS Number | 2782-91-4 | Molecular Weight | 132.227 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 245.0±9.0 °C at 760 mmHg | |
| Molecular Formula | C5H12N2S | Melting Point | 75-77 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 102.0±18.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Particulate matter 2.5 induces autophagy via inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin kinase signaling pathway in human bronchial epithelial cells.
Mol. Med. Report. 12 , 1914-22, (2015) Particulate matter 2.5 (PM2.5) is a significant risk factor for asthma. A recent study revealed that autophagy was associated with asthma pathogenesis. However, the specific mechanisms underlying PM2.5-induced autophagy in asthma have remained elusive. In the... |
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Acrolein induction of oxidative stress and degranulation in mast cells.
Environ. Toxicol. 29(8) , 908-15, (2014) Increases in asthma worldwide have been associated epidemiologically with expanding urban air pollution. The mechanistic relationship between airway hyper-responsiveness, inflammation, and ambient airborne triggers remains ambiguous. Acrolein, a ubiquitous al... |
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CoBr2-TMTU-zinc catalysed-Pauson-Khand reaction.
Chem. Commun. (Camb.) 48(66) , 8183-5, (2012) A cobalt-TMTU complex, derived from the in situ reduction of CoBr(2) with Zn in the presence of TMTU, can catalyze Pauson-Khand reaction at a balloon pressure of CO, which enables the synthesis of structurally diverse cyclopentenones. This catalytic system wo... |
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[Effect of thyroid deficiency on cutaneous nerve development in chickens].
C. R. Seances. Acad. Sci. III. 294(1) , 19-24, (1982)
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Morphometric analysis of the cerebellar Purkinje cell in the developing normal and hypothyroid chick.
Int. J. Dev. Neurosci. 5(4) , 345-55, (1987) A morphometric analysis of Purkinje cells in the developing cerebellar cortex of the chick was performed in normal animals and embryos made hypothyroid by one or two spaced injections of tetramethylthiourea. Profiles of 162 Purkinje cells, from Golgi-Cox trea... |
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Studies on the goitrogenic mechanism of action of N,N,N',N'-tetramethylthiourea.
Toxicology 217(2-3) , 169-75, (2006) N,N,N',N'-Tetramethylthiourea (TMTU) is a rat goitrogen inducing thyroid hyperplasia, hypertrophy, and tumor formation. Little is known about the exact underlying mechanism of action. As thyroid peroxidase (TPO) and type I iodothyronine deiodinase (ID-I) have... |
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Sampling and analytical determination of airborne tetramethyl and ethylene thiourea.
Am. Ind. Hyg. Assoc. J. 41(2) , 91-7, (1980) Tetramethyl and ethylene thiourea are collected from air using midget impingers containing 15 mL water. Ethylene thiourea may also be collected from air using PVC or cellulose ester membrane filters which are then extracted with water. Pentacyanoamineferrate ... |
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DNA-binding activity of NF-kappaB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase.
Mol. Immunol. 45(15) , 3984-9, (2008) N-Acetylcysteine (NAC) has been widely used as an antioxidant in research, however, it has also been found to reduce the binding of TNF to its receptor independent of its antioxidative role. In this study, we investigated the effect of NAC on NF-kappaB activa... |
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Anthralin stimulates keratinocyte-derived proinflammatory cytokines via generation of reactive oxygen species.
Inflamm. Res. 47(4) , 174-81, (1998) Topical application of anthralin, used in the treatment of psoriasis, is often accompanied by severe skin inflammation, presumably due to free radical products of the drug. The role of inflammatory cytokines and their induction by anthralin-derived reactive o... |
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Role of the thyroid in the involution of the mesonephric Malpighian corpuscles in the chick embryo.
Biol. Cell 51(1) , 97-104, (1984) The mesonephros of the chick embryo normally begins to regress during the second half of embryonic life. Experimental methods, such as adenohypophysis grafting, hypophysectomy or use of antithyroid drugs, which stimulate or depress the thyroid function of the... |