ST638
ST638 structure
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Common Name | ST638 | ||
|---|---|---|---|---|
| CAS Number | 107761-24-0 | Molecular Weight | 354.423 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 611.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H18N2O3S | Melting Point | 134-135.5ºC | |
| MSDS | Chinese USA | Flash Point | 323.5±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The effect of a naphthalene derivative, TEI-6472, on histamine release and tyrosine phosphorylation in rat basophilic leukemia cells.
Int. J. Immunopharmacol. 17(5) , 433-41, (1995) It is well known that rat basophilic leukemia cells (RBL-2H3) express high-affinity IgE receptors (Fc epsilon RI) and that the aggregation of these receptors causes the release of chemical mediators. When RBL-2H3 cells are sensitized with IgE antibody and sub... |
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Inhibition of fast sodium current in rabbit ventricular myocytes by protein tyrosine kinase inhibitors.
Pflugers Arch. 446(4) , 485-91, (2003) The present study investigated the effects of protein tyrosine kinase inhibitors on the fast sodium current ( I(Na)) in rabbit ventricular myocytes. Single rabbit ventricular myocytes were isolated enzymatically using Langendorff perfusion. I(Na) was recorded... |
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Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes.
Cell Physiol. Biochem. 13(3) , 165-72, (2003) Polymorphonuclear leukocytes (neutrophils) release a variety of toxic agents--proteins and reactive oxygen species (ROS)--that are used to inactivate foreign microorganisms in the non-specific immune response. This study was undertaken to compare intracellula... |
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Tyrosine kinase inhibitor markedly suppresses the development of coronary lesions induced by long-term treatment with platelet-derived growth factor in pigs in vivo.
J. Cardiovasc. Pharmacol. 29(4) , 536-45, (1997) Platelet-derived growth factor (PDGF) plays an important role in the development of coronary atherosclerosis. However, it remains to be examined what morphologic and functional changes are induced in vivo by the long-term treatment with PDGF itself or what ph... |
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Tyrosine and calcium/calmodulin kinases are common signaling components in the generation of reactive oxygen species in human lymphocytes.
Life Sci. 65(20) , 2135-42, (1999) This study examined the signaling mechanism involved in the generation of reactive oxygen species (ROS) in human lymphocytes activated by formyl-Met-Leu-Phenylalanine (fMLP; 200 nmol/L) or phorbol-myristate-acetate (PMA; 100 nmol/L). ROS were monitored spectr... |
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Regulation of transient outward current in human atrial myocytes by protein tyrosine kinase pathway.
J. Cardiovasc. Electrophysiol. 13(9) , 927-35, (2002) Regulation of transient outward current (I(to)) in human myocytes is unclear. The present study investigated the effect of protein tyrosine kinase (PTK) inhibitors on I(to) in human atrial myocytes.Atrial myocytes were isolated enzymatically from biopsies of ... |
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Scraped-wounding causes activation and association of C-Src tyrosine kinase with microtubules in cultured keratinocytes.
Cell Struct. Funct. 25(6) , 351-9, (2000) In order to elucidate the function of c-Src in keratinocytes, we studied the intracellular distribution of its active and inactive form in cultured normal human keratinocyte, using anti-c-Src monoclonal antibody clone 28, which recognizes the active form of c... |
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Investigation of the role of protein kinase C and tyrosine kinases during the rapid and sustained release of superoxide from adherent human neutrophils.
Biochem. Soc. Trans. 24(1) , 67S, (1996)
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The effect of tyrosine kinase inhibitors on IgE-mediated histamine release from human lung mast cells and basophils.
Inflamm. Res. 47(3) , 137-43, (1998) To investigate the role of tyrosine kinases (TK) in IgE-mediated signal transduction in human lung mast cells (HLMC) and basophils.Peripheral blood basophils (n > or = 4) and human lung mast cells (n > or = 6).Cells were preincubated with TK inhibitor for 15 ... |
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The characterization of tyrosine phosphorylation of 78 and 92 kDa proteins in rat basophilic RBL-2H3 cells.
Inflamm. Res. 45(9) , 452-6, (1996) Previously, we have demonstrated that tyrosine phosphorylation of 78 and 92 kDa proteins in rat basophilic leukemia cells (RBL-2H3) is involved in a signal transduction system for high-affinity IgE receptor (Fc epsilon RI)-mediated histamine secretion. Howeve... |