2,2,2-Cryptand
2,2,2-Cryptand structure
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Common Name | 2,2,2-Cryptand | ||
|---|---|---|---|---|
| CAS Number | 23978-09-8 | Molecular Weight | 376.488 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 513.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H36N2O6 | Melting Point | 68-71 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 144.2±25.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Rapid synthesis of a 5'-fluorinated oligodeoxy-nucleotide: a model antisense probe for use in imaging with positron emission tomography (PET).
Bioorg. Med. Chem. Lett. 8(11) , 1317-20, (1998) 5'-Deoxy-5'-fluoro-O4-methylthymidine was synthesized by the reaction of the corresponding 5'-O-tosylate with KF in the presence of Kryptofix [222] and coupled to a 5'-phosphoramidite-activated CPG-bound oligodeoxynucleotide. The sequence of reactions and pur... |
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Simultaneous analysis of FDG, ClDG and Kryptofix 2.2.2 in [18F]FDG preparation by high-performance liquid chromatography with UV detection.
Nucl. Med. Biol. 35(2) , 239-44, (2008) A practical, sensitive and rapid analytical method was established and validated for chemical impurity tests of 2-deoxy-2-fluoro-d-glucose (FDG), 2-deoxy-2-chloro-d-glucose (ClDG) and Kryptofix 2.2.2 (K-222) in [18F]FDG. This method was based on precolumn der... |
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Transport of alkali cations through thin lipid membranes by (222)C10-cryptand, an ionizable mobile carrier.
J. Membr. Biol. 89(3) , 251-67, (1986) The kinetics of K+ and Na+ transport across the membrane of large unilamellar vesicles (L.U.V.) were compared at two pH's, with two carriers: (222)C10-cryptand (diaza-1,10-decyl-5-hexaoxa-4,7,13,16,21,24-bicyclo[8.8.8.]+ ++hexacosane) and valinomcyin, i.e. an... |
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Cation radius effects on the helix-coil transition of DNA. Cryptates and other large cations.
Biophys. J. 57(4) , 829-34, (1990) Most polyelectrolyte theories of the effect of ions on the thermal melting of DNA assume that the predominant influence of the cations comes through their charge. Ion size and structure are treated, for analytic convenience, as negligible variables. We have e... |
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Determination of residual Kryptofix 2.2.2 levels in [18F]-labeled radiopharmaceuticals for human use.
Appl. Radiat. Isot. 65(12) , 1359-62, (2007) 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Kryptofix 2.2.2) is used in the routine preparation of [18F]-labeled tracers employed in positron emission tomography (PET) imaging. Confirming the absence of Kryptofix in radiopharmaceuticals is a q... |
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Comparison of two cryptand separator columns for the determination of trace chloride in semiconductor-grade nitric acid.
J. Chromatogr. A. 1085(1) , 33-6, (2005) Improved ion-chromatographic approaches for measuring trace chloride in nitric acid are presented. Two columns, the IonPac Cryptand A1 and a higher-capacity Cryptand prototype, were tested and compared. Also, the use of a Continuously Regenerated Anion Trap C... |
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Back-to-back "one-pot" [18F]FDG syntheses in a single Siemens-CTI chemistry process control unit.
Nucl. Med. Biol. 23(4) , 497-501, (1996) Simple changes in the chemistry, plumbing, and programming of the Siemens-CTI chemistry process control unit (CPCU) effectively double its output by enabling two back-to-back "1-pot" syntheses of 2-[18F]fluoro-2-deoxy-D-glucose in a single unit. Replacement o... |
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Evaluation of potential strontium chelators in an octanol-water system.
Health Phys. 65(5) , 541-4, (1993) 90Sr has a physical half-life of sufficient duration to make it a potentially dangerous contaminant from nuclear accidents and radioactive wastes. In the present study, the efficacy of 16 compounds as potential chelators of strontium was tested in vitro. Stro... |
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Thin layer chromatographic detection of kryptofix 2.2.2 in the routine synthesis of [18F]2-fluoro-2-deoxy-D-glucose.
Int. J. Rad. Appl. Instrum. B 16(4) , 385-7, (1989) A simple procedure for the detection of 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo (8.8.8) hexacosane (Kryptofix 2.2.2) in the final solution of [18F]FDG prepared by the aminopolyether supported nucleophilic substitution of 1,3,4,6-tetra-O-acetyl 2-O-trifluoro... |
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Removal of the 2.2.2 cryptand (Kryptofix 2.2.2) from 18FDG by cation exchange.
Int. J. Rad. Appl. Instrum. A. 42(12) , 1189-93, (1991) The 2.2.2 cryptand [4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo-(8.8.8)-hexacosane] was trapped efficiently on Dowex AG50W-X8 (100-200 mesh) cation exchange resin. The concentration of the 2.2.2 cryptand in water with 0.1-2% methanol, or in 1 N HCl, was decreas... |