Menatetrenone
Menatetrenone structure
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Common Name | Menatetrenone | ||
|---|---|---|---|---|
| CAS Number | 863-61-6 | Molecular Weight | 444.648 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 570.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C31H40O2 | Melting Point | 350ºC | |
| MSDS | USA | Flash Point | 208.3±27.1 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Retinoids Bias Integrin Expression and Function in Cutaneous T-Cell Lymphoma.
J. Invest. Dermatol. 135 , 2102-8, (2015) Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of malignancies characterized by accumulation of malignant T-cells within the skin. Retinoids, metabolic derivatives, and synthetic analogs of vitamin A embody an effective CTCL therapy with over three... |
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The antiosteoporotic effects of Cheonggukjang containing vitamin k2 (menaquinone-7) in ovariectomized rats.
J. Med. Food 17(12) , 1298-305, (2014) The effect of dietary vitamin K2 (menaquinone-7, MK-7) and cheonggukjang (CGJ) on the prevention of ovariectomy (OVX)-induced bone loss was studied in rats. Female Sprague-Dawley rats were divided into eight groups: sham-operated; OVX control; OVX treated wit... |
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A simple and rapid creatinine sensing via DLS selectivity, using calix[4]arene thiol functionalized gold nanoparticles.
Talanta 147 , 590-7, (2015) A new, simple, ultra-sensitive and selective approach has been reported for the "on spot" colorimetric detection of creatinine based on calix[4]arene functionalized gold nanoparticles (AuNPs) with excellent discrimination in the presence of other biomolecules... |
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Synthesis of novel vitamin K2 analogues with modification at the ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists.
J. Med. Chem. 54 , 4269-73, (2011) Vitamin K(2) is a ligand for a nuclear receptor, steroid and xenobiotic receptor (SXR), that induces the gene expressions of CYP3A4. We synthesized vitamin K(2) analogues with hydroxyl or phenyl groups at the ω-terminal of the side chain. The up-regulation of... |
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Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K.
J. Med. Chem. 54 , 4918-22, (2011) Vitamin K(2) has been demonstrated to induce gene expression related to bone formation through a nuclear steroid and xenobiotic receptor (SXR). We synthesized new vitamin K analogues with the same isoprene side chains symmetrically introduced at the 2 and 3 p... |
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Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.
J. Biol. Chem. 288(46) , 33071-80, (2013) Mice have the ability to convert dietary phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) and store the latter in tissues. A prenyltransferase enzyme, UbiA prenyltransferase domain-containing 1 (UBIAD1), is involved in this conversion. There is evid... |
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Dietary sesame seed and its lignan, sesamin, increase tocopherol and phylloquinone concentrations in male rats.
J. Nutr. 143(7) , 1067-73, (2013) We have shown that intake of sesame seed and its lignan increases vitamin E concentrations and decreases urinary excretion levels of vitamin E metabolites in male Wistar rats, suggesting inhibition of vitamin E catabolism by sesame lignan. The aim of this stu... |
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Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.
Mol. Nutr. Food. Res. 56(6) , 912-22, (2012) The mechanism for increased bleeding and decreased vitamin K status accompanying vitamin E supplementation is unknown. We hypothesized that elevated hepatic α-tocopherol (α-T) concentrations may stimulate vitamin K metabolism and excretion. Furthermore, α-T m... |
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Modelling the atypical absorption of menatetrenone and the metabolism to its epoxide: effect of VKORC1 polymorphism.
J. Clin. Pharm. Ther. 36 , 390-398, (2011) This study aimed to model the atypical absorption of menatetrenone and its epoxide metabolite and to examine the influence of the single nucleotide polymorphism (SNP) of vitamin K2 epoxide reductase complex subunit 1 (VKORC1) on the pharmacokinetics.After the... |
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Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone.
J. Pediatr. Endocrinol. Metab. 25(3-4) , 307-12, (2012) Long-term treatment with glucocorticoids can induce bone loss and increase fracture risks.To compare the efficacy of a 12-month treatment between alfacalcidol and menatetrenone in preventing bone loss in children treated with long-term glucocorticoids.Twenty ... |