Methotrexate
Methotrexate structure
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Common Name | Methotrexate | ||
|---|---|---|---|---|
| CAS Number | 59-05-2 | Molecular Weight | 454.439 | |
| Density | 1.4080 | Boiling Point | 561.26°C | |
| Molecular Formula | C20H22N8O5 | Melting Point | 195°C | |
| MSDS | Chinese USA | Flash Point | 11℃ | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.
Br. J. Cancer 111(5) , 874-82, (2014) Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all-trans retinoic acid (ATRA)), which promotes differentiation of promyelocytic blasts. Although co-administration of arsenic trioxide (ATO) with ATRA has emerged as an effectiv... |
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Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells.
MAbs 7(2) , 403-12, (2015) Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells. Four 2A peptides derived from the foot-and-m... |
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TLR signaling modulates side effects of anticancer therapy in the small intestine.
J. Immunol. 194(4) , 1983-95, (2015) Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology remains to be clarified, and there is so far no successful th... |
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Prediction of methotrexate CNS distribution in different species - influence of disease conditions.
Eur. J. Pharm. Sci. 57 , 11-24, (2014) Children and adults with malignant diseases have a high risk of prevalence of the tumor in the central nervous system (CNS). As prophylaxis treatment methotrexate is often given. In order to monitor methotrexate exposure in the CNS, cerebrospinal fluid (CSF) ... |
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Simple and reliable HPLC method for the monitoring of methotrexate in osteosarcoma patients.
J. Chromatogr. Sci. 52(7) , 590-5, (2014) Methotrexate (MTX) is a dihydrofolate reductase inhibitor that is used for the treatment of tumors and autoimmune diseases. Several automated binding assays are used in clinical practice and numerous chromatographic methods have been developed toward higher s... |
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Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor.
Biotechnol. Bioeng. 112(2) , 308-21, (2015) Tobacco BY-2 cells have emerged as a promising platform for the manufacture of biopharmaceutical proteins, offering efficient protein secretion, favourable growth characteristics and cultivation in containment under a controlled environment. The cultivation o... |
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Noncompetitive inhibition of proton-coupled folate transporter by myricetin.
Drug Metab. Pharmacokinet. 29(4) , 312-6, (2014) Myricetin is a flavonoid that has recently been suggested to interfere with the intestinal folate transport system. The present study was conducted to examine that possibility, focusing on its inhibitory effect on proton-coupled folate transporter (PCFT) as t... |
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Photocatalytic degradation of selected anticancer drugs and identification of their transformation products in water by liquid chromatography-high resolution mass spectrometry.
J. Chromatogr. A. 1362 , 135-44, (2014) A study on the fate of two antineoplastic drugs, methotrexate and doxorubicin, in the aquatic environment is presented. The investigation involved a study of their decomposition under dark experiments, homogeneous photolysis and heterogeneous photocatalysis u... |
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A HPLC-SRM-MS based method for the detection and quantification of methotrexate in urine at doses used in clinical practice for patients with rheumatological disease: a potential measure of adherence.
Analyst 140(6) , 1981-7, (2015) Rheumatoid arthritis (RA) is a common autoimmune disease that causes significant disability and reduced life expectancy. The folate antagonist methotrexate (MTX) is first-line therapy for RA when used weekly at low doses (5-25 mg). However, the true rate of a... |
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High performance liquid chromatography coupled to mass spectrometry for profiling and quantitative analysis of folate monoglutamates in tomato.
Food Chem. 179 , 76-84, (2015) Folates are essential micronutrients for animals as they play a major role in one carbon metabolism. Animals are unable to synthesize folates and obtain them from plant derived food. In the present study, a high performance liquid chromatography coupled to ma... |