4-Fluorobenzyl bromide

4-Fluorobenzyl bromide Structure
4-Fluorobenzyl bromide structure
Common Name 4-Fluorobenzyl bromide
CAS Number 459-46-1 Molecular Weight 189.025
Density 1.5±0.1 g/cm3 Boiling Point 195.9±15.0 °C at 760 mmHg
Molecular Formula C7H6BrF Melting Point N/A
MSDS Chinese USA Flash Point 74.8±15.3 °C
Symbol GHS05
GHS05
Signal Word Danger

Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors.

Bioorg. Med. Chem. 14(16) , 5742-55, (2006)

Because of its essential role in HIV replication and lack of human counterpart, HIV integrase is an attractive target for the development of novel anti-AIDS agents. Among the recently developed integrase inhibitors, only the alpha,gamma-diketo acid (DKA) comp...

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

ChemMedChem 4(8) , 1311-6, (2009)

The cellular protein lens epithelium-derived growth factor, or transcriptional coactivator p75 (LEDGF/p75), plays a crucial role in HIV integration. The protein-protein interactions (PPIs) between HIV-1 integrase (IN) and its cellular cofactor LEDGF/p75 may t...

Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.

J. Med. Chem. 51(24) , 8057-67, (2008)

Imaging of programmed cell death (apoptosis) is important in the assessment of therapeutic response in oncology and for diagnosis in cardiac and neurodegenerative disorders. The executioner caspases 3 and 7 ultimately effect cellular death, thus providing sel...