tioxolone
tioxolone structure
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Common Name | tioxolone | ||
|---|---|---|---|---|
| CAS Number | 4991-65-5 | Molecular Weight | 168.170 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 377.8±44.0 °C at 760 mmHg | |
| Molecular Formula | C7H4O3S | Melting Point | 158-160 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 182.3±28.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one (tioxolone).
Acta Crystallogr. C 60(Pt 6) , o395-6, (2004) The planar molecules of 6-hydroxy-1,3-benzoxathiol-2-one, C(7)H(4)O(3)S, are linked by extensive O-H.O and C-H.O hydrogen bonding and are further stablilized by face-to-face pi-pi interactions. |
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[Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one (01 1)].
Arzneimittelforschung 19(8) , 1298-304, (1969)
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Contact dermatitis from thioxolone.
Contact Dermatitis 29(2) , 96, (1993)
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Carbonic anhydrase inhibitors: Thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?
Bioorg. Med. Chem. Lett. 18(14) , 3938-41, (2008) Inhibition of 13 mammalian isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), CA I-XV, with thioxolone (6-hydroxy-1,3-benzoxathiol-2-one) and two sulfonamides was investigated. Thioxolone was inefficient for generating isozyme-selective inhibi... |
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Mechanism of allergic cross-reactions--I. Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody.
Mol. Immunol. 28(6) , 641-54, (1991) A recently developed solid-phase binding assay was used to investigate the specificity of ligand binding to a mouse monoclonal anti-dinitrophenyl IgE [IgE(aDNP)]. All DNP-amino acids, that were tested, inhibited the binding of radio-labeled IgE(aDNP) to DNP c... |
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Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
Biochemistry 47(10) , 3174-84, (2008) This paper examines the functional mechanism of thioxolone, a compound recently identified as a weak inhibitor of human carbonic anhydrase II by Iyer et al. (2006) J. Biomol. Screening 11, 782-791 . Thioxolone lacks sulfonamide, sulfamate, or hydroxamate func... |
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Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).
J. Antimicrob. Chemother. 65(12) , 2566-73, (2010) We sought to identify and characterize new inhibitors of MurA and MurZ, which are enzymes involved in the early stages of bacterial peptidoglycan synthesis.A library of ∼650 000 compounds was screened for inhibitors of Escherichia coli MurA in an endpoint ass... |
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Contact dermatitis to thioxolone.
Contact Dermatitis 7(4) , 213-4, (1981)
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Contact dermatitis to thioxolone.
Contact Dermatitis 17(4) , 250-1, (1987)
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Facile regioselective synthesis and antimicrobial activity of heterocycle-phosphor esters. Abdou WM, et al.
Monatsh. Chem 145(4) , 675-82, (2014)
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