1,3-Diphenylpropane-1,3-dione
1,3-Diphenylpropane-1,3-dione structure
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Common Name | 1,3-Diphenylpropane-1,3-dione | ||
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| CAS Number | 120-46-7 | Molecular Weight | 224.255 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 357.4±0.0 °C at 760 mmHg | |
| Molecular Formula | C15H12O2 | Melting Point | 77-79 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 146.9±20.2 °C | |
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Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
J. Med. Chem. 48 , 2906-15, (2005) Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of selective inhibitors of these proteins has proved problemat... |
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A glimpse of the inner workings of the templated site.
Chem. Commun. (Camb.) (2) , 165-7, (2009) This is the first direct experimental probe, using EXAFS, of the active site within molecularly imprinted polymers and paves the way to a more detailed understanding of the inner workings of molecular imprinting. |
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Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.
J. Med. Chem. 51 , 6478-94, (2008) Hormone sensitive lipase (HSL) has been recently implicated in diabetes and obesity, prompting attempts to discover new HSL inhibitors. Toward this end, we explored the pharmacophoric space of HSL inhibitors using four diverse sets of compounds. Subsequently,... |
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Faster Synthesis of Beta-Diketonate Ternary Europium Complexes: Elapsed Times & Reaction Yields.
PLoS ONE 10 , e0143998, (2015) β-diketonates are customary bidentate ligands in highly luminescent ternary europium complexes, such as Eu(β-diketonate)3(L)2, where L stands for a nonionic ligand. Usually, the syntheses of these complexes start by adding, to an europium salt such as EuCl3(H... |
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Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells.
Int. J. Dev. Neurosci. 29(7) , 701-10, (2011) Neuroblastoma (NB) is the most prevalent pediatric solid tumor and a leading cause of cancer-related death in children. In the present study, a novel cytotoxic role for the dietary compounds, curcumin, andrographolide, wedelolactone, dibenzoylmethane, and tan... |
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Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
J. Nat. Prod. 70 , 1884-8, (2007) Recent data suggest that curcumin, a phytochemical with cancer chemopreventive potential, might be useful in the treatment of several solid and hematological malignancies. DNA topoisomerases (topos) are the target of several drugs commonly used in cancer chem... |
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A novel PVC-membrane optical sensor for highly sensitive and selective determination of UO2(2+) ion based on a recently synthesized benzo-substituted macrocyclic diamide and dibenzoylmethane.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 77(1) , 319-23, (2010) A highly sensitive ion-selective bulk optode membrane for sensing UO2(2+) ion based on plasticized poly(vinyl chloride) containing 6,7,9,10,12,13,15,16,23,24,25,26-dodecahydrodibenzo[n,v][1,4,7,10,13,17,20]pentaoxa-diazacyclotricosine-22,27-dione as ionophore... |
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Optical properties and spectroscope parameters of Sm(DBM)(3)Phen-doped poly(methyl methacrylate).
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 72(3) , 554-60, (2009) Rare-earth complex Sm(DBM)(3)Phen-doped poly(methyl methacrylate) was synthesized and its absorption and luminescence spectra were studied. The relationship between the coordinate environment of rare-earth ions and the Judd-Ofelt intensity parameter Omega(2) ... |
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Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition.
Biopharm. Drug Dispos. 32(2) , 65-75, (2011) The pharmacokinetic disposition of a dietary cancer chemopreventive compound dibenzoylmethane (DBM) was studied in male Sprague-Dawley rats after intravenous (i.v.) and oral (p.o.) administrations. Following a single i.v. bolus dose, the mean plasma clearance... |
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Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 852(1-2) , 56-61, (2007) A highly sensitive and simple high-performance liquid chromatographic (HPLC) assay has been developed and validated for the quantification of dibenzoylmethane (DBM) in rat plasma. DBM and internal standard (I.S.) 1-(5-chloro-2-hydroxy-4-methylphenyl)-3-phenyl... |