Phenytoin sodium
Phenytoin sodium structure
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Common Name | Phenytoin sodium | ||
|---|---|---|---|---|
| CAS Number | 630-93-3 | Molecular Weight | 274.250 | |
| Density | N/A | Boiling Point | 428.2ºC at 760 mmHg | |
| Molecular Formula | C15H11N2NaO2 | Melting Point | 290-299ºC | |
| MSDS | Chinese USA | Flash Point | 212.8ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Comparison of retinal nerve fiber layer thickness in vivo and axonal transport after chronic intraocular pressure elevation in young versus older rats.
PLoS ONE 9(12) , e114546, (2014) To compare in young and old rats longitudinal measurements of retinal nerve fiber layer thickness (RNFLT) and axonal transport 3-weeks after chronic IOP elevation.IOP was elevated unilaterally in 2- and 9.5-month-old Brown-Norway rats by intracameral injectio... |
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Contribution of glucose to crystallization of phenytoin in injectable dosage form by dilution with infusion fluids.
Chem. Pharm. Bull. 62(10) , 989-93, (2014) The crystallization of phenytoin occurring after its dilution with infusion fluid is a major concern in the clinical use of injectable phenytoin. To gain further understanding of the crystallization, this study assessed details of the involvement of glucose i... |
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Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1029-38, (2015) Add-on therapy is a common strategy to improve efficacy and tolerability of antiepileptic drugs (AEDs). Anticonvulsant potential and appropriate safety of docosahexaenoic acid (DHA) makes it a promising candidate for combination therapy. We evaluated influenc... |
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Nanoliposomal Nitroglycerin Exerts Potent Anti-Inflammatory Effects.
Sci. Rep. 5 , 16258, (2015) Nitroglycerin (NTG) markedly enhances nitric oxide (NO) bioavailability. However, its ability to mimic the anti-inflammatory properties of NO remains unknown. Here, we examined whether NTG can suppress endothelial cell (EC) activation during inflammation and ... |
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Evaluation of a thermoprotective gel for hydrodissection during percutaneous microwave ablation: in vivo results.
Cardiovasc. Intervent. Radiol. 38 , 722-30, (2015) To evaluate whether thermoreversible poloxamer 407 15.4 % in water (P407) can protect non-target tissues adjacent to microwave (MW) ablation zones in a porcine model.MW ablation antennas were placed percutaneously into peripheral liver, spleen, or kidney (tar... |
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Feasibility of catheter-directed intraluminal irreversible electroporation of porcine ureter and acute outcomes in response to increasing energy delivery.
J. Vasc. Interv. Radiol. 26 , 1059-66, (2015) To evaluate the feasibility of focal intraluminal irreversible electroporation (IRE) in the ureter with a novel electrode catheter and to study the treatment effects in response to increasing pulse strength.Five IRE treatment settings were each evaluated twic... |
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CRF antagonism within the ventral tegmental area but not the extended amygdala attenuates the anxiogenic effects of cocaine in rats.
Pharmacol. Biochem. Behav. 138 , 148-55, (2015) In addition to its initial rewarding effects, cocaine has been shown to produce profound negative/anxiogenic actions. Recent work on the anxiogenic effects of cocaine has examined the role of corticotropin releasing factor (CRF), with particular attention pai... |
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Evidence for orexinergic mechanisms in migraine.
Neurobiol. Dis. 74 , 137-43, (2015) To examine the effect of the orexinergic blockade with a dual orexin receptor antagonist (DORA) on experimental models of peripheral and central trigeminal as well as cortical activation relevant to migraine and migraine aura.In this study we used a precursor... |
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Comparisons of phenotype and immunomodulatory capacity among rhesus bone-marrow-derived mesenchymal stem/stromal cells, multipotent adult progenitor cells, and dermal fibroblasts.
J. Med. Primatol. 43(4) , 231-41, (2014) Potent immunomodulatory effects have been reported for mesenchymal stem/stromal cells (MSCs), multipotent adult progenitor cells (MAPCs), and fibroblasts. However, side-by-side comparisons of these cells specifically regarding immunophenotype, gene expression... |
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Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling.
Endocrinology 156 , 2608-18, (2015) Throughout most of the ovulatory cycle, estrogen negative feedback restrains the GnRH neuronal system. Just before ovulation, however, estrogen negative feedback is removed to permit stimulation of the preovulatory GnRH/LH surge (positive feedback) by the cir... |