4-Formamidoantipyrine
4-Formamidoantipyrine structure
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Common Name | 4-Formamidoantipyrine | ||
|---|---|---|---|---|
| CAS Number | 1672-58-8 | Molecular Weight | 231.251 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 374.5±52.0 °C at 760 mmHg | |
| Molecular Formula | C12H13N3O2 | Melting Point | 189-192ºC | |
| MSDS | Chinese USA | Flash Point | 180.3±30.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies.
J. Pharm. Biomed. Anal. 71 , 173-8, (2012) In order to evaluate the pharmacokinetics of metamizol in the presence of morphine in arthritic rats, after subcutaneous administration of the drugs, an easy, rapid, sensitive and selective analytical method was proposed and validated. The four main metamizol... |
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Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.
Eur. J. Clin. Pharmacol. 57(6-7) , 461-5, (2001) We previously found that, compared with healthy subjects. asymptomatic hepatitis-B virus (HBV) carriers displaying slow acetylator phenotype demonstrate a significant prolongation of the elimination half-life of 4-methylaminoantipyrine (MAA) and a decrease in... |
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Simple high-performance liquid chromatographic method for simultaneous determination of aminopyrine and its metabolites.
J. Chromatogr. A. 421(1) , 198-205, (1987)
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[Metamizol--acute overdose with suicidal intent].
Dtsch. Med. Wochenschr. 108(46) , 1761-4, (1983) An 18-year-old girl swallowed 98 tablets of Novalgin (corresponding to 49 g metamizole) with suicidal intent. After stomach lavage she received forced diuresis for 14 hours. Metamizole metabolites in serum and urine were measured by thin-layer chromatography.... |
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Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.
Liver 22(6) , 507-13, (2002) We report about a 66-year-old-male patient who was hospitalized with generalized exanthema and increase of liver enzymes after intake of metamizole because of flue-like symptoms. Despite initial high dose steroids, disease activity persisted, and therefore li... |
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High-performance liquid chromatographic analysis of dipyrone metabolites to study their formation in human liver microsomes.
Pharm. Res. 13(8) , 1272-5, (1996)
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Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products.
Water Res. 42(10-11) , 2698-706, (2008) The photochemical behaviour of three relevant metabolites of the analgesic and antipyretic drug dipyrone, 4-methylaminoantipyrine (4-MAA), 4-formylaminoantipyrine (4-FAA) and 4-acetylaminoantipyrine (4-AAA), was evaluated under simulated solar irradiation (Su... |
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Plasma kinetics of dipyrone metabolites in rapid and slow acetylators.
Eur. J. Clin. Pharmacol. 27(4) , 453-8, (1984) The pharmacokinetics of the dipyrone metabolites 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA) were evaluated following the administration of a single oral 1.0 g dose of dipyrone to 23 h... |
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Effect of dipyrone, acetylsalicylic acid and acetaminophen on human neutrophil chemotaxis.
Eur. J. Clin. Invest. 14(6) , 440-3, (1984) Dipyrone metabolites 4-methylaminoantipyrine (MAA) and 4-formylaminoantipyrine (FAA) as well as acetylsalicylic acid inhibited neutrophil migration toward zymosan-activated serum. Inhibition was maximal (76.8 +/- 19.0; 79.2 +/- 12.5 and 80.0 +/- 4.4%, respect... |
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Validity of saliva samples for the estimation of dipyrone metabolites pharmacokinetics.
Arzneimittelforschung 43(11) , 1204-8, (1993) Plasma and saliva pharmacokinetics of dipyrone (CAS 5907-38-0) metabolites, 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA), has been studied in 10 healthy volunteers, after oral administr... |