THIORIDAZINE
THIORIDAZINE structure
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Common Name | THIORIDAZINE | ||
|---|---|---|---|---|
| CAS Number | 50-52-2 | Molecular Weight | 370.574 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 515.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H26N2S2 | Melting Point | 72-74° | |
| MSDS | N/A | Flash Point | 265.7±30.1 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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[Simultaneous determination of 10 unapproved sedative drugs in feeds by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry].
Se Pu 30(5) , 457-62, (2012) A new analytical method using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was developed for screening and confirmation of 10 unapproved sedative drugs in feeds. The samples were extracted using the solut... |
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A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.
Eukaryotic Cell 12(2) , 278-87, (2013) New, more accessible therapies for cryptococcosis represent an unmet clinical need of global importance. We took a repurposing approach to identify previously developed drugs with fungicidal activity toward Cryptococcus neoformans, using a high-throughput scr... |
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Why and how thioridazine in combination with antibiotics to which the infective strain is resistant will cure totally drug-resistant tuberculosis.
Expert Rev. Anti. Infect. Ther. 10(8) , 869-73, (2012) Over a period of 14 years, the authors have studied thioridazine, an old neuroleptic, that has been shown to have in vitro activity against intracellular Mycobacterium tuberculosis, regardless of its antibiotic resistance status, thioridazine cures infected m... |
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Synthesis, characterization and electrical properties of peripherally tetra-aldazine substituted novel metal free phthalocyanine and its zinc(II) and nickel(II) complexes.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 105 , 550-6, (2013) The novel phthalonitrile containing azine segment and its corresponding tetra aldazine substituted metal free- and metallo-phthalocyanines (Zn(II) and Ni(II)) were synthesized and characterized by IR, (1)H NMR, Mass, UV-Vis spectroscopy and elemental analysis... |
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Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells.
Cell 149(6) , 1284-97, (2012) Selective targeting of cancer stem cells (CSCs) offers promise for a new generation of therapeutics. However, assays for both human CSCs and normal stem cells that are amenable to robust biological screens are limited. Using a discovery platform that reveals ... |
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Thioridazine potentiates the effect of a beta-lactam antibiotic against Staphylococcus aureus independently of mecA expression.
Res. Microbiol. 164(2) , 181-8, (2013) The neuroleptic antipsychotic derivate thioridazine has been shown to increase the susceptibility of a methicillin-resistant Staphylococcus aureus (MRSA) isolate towards dicloxacillin. The aim of this study was to investigate the combinatorial effect of the t... |
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Impact of probe compound in MRP2 vesicular transport assays.
Eur. J. Pharm. Sci. 46 , 100-105, (2012) MRP2 is an efflux transporter that is expressed mainly in the canalicular membrane of hepatocytes, where it expels polar and ionic compounds into the bile. MRP2 is also present in the apical membrane of enterocytes and epithelial cells of proximal tubules of ... |
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Anti-angiogenic effects of thioridazine involving the FAK-mTOR pathway.
Microvasc. Res. 84(3) , 227-34, (2012) Thioridazine is a type of anti-psychotic drug that also includes anti-tumor activity. In this study, we assessed the effects of thioridazine, as a novel anti-angiogenic agent, on the suppression of angiogenesis-mediated cell proliferation. Thioridazine was fo... |
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Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine.
In Vivo 26(2) , 231-6, (2012) Multidrug-resistant tuberculosis (MDRTB) infections that continue to increase in frequency globally have progressed to become extremely drug-resistant tuberculosis (XDRTB). The therapeutic problems associated with MDRTB pale in comparison to those for XDRTB w... |
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Cardiotoxicity and prescription of thioridazine in New Zealand.
Aust. N. Z. J. Psychiatry 36(4) , 492-8, (2002) To review the production of cardiac arrhythmia by thioridazine, and consider the role of government regulation in light of antipsychotic prescribing trends in New Zealand.We conducted a focused literature review on psychotropic-induced cardiotoxicity, includi... |