7-Methoxy-4-(trifluoromethyl)coumarin
7-Methoxy-4-(trifluoromethyl)coumarin structure
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Common Name | 7-Methoxy-4-(trifluoromethyl)coumarin | ||
|---|---|---|---|---|
| CAS Number | 575-04-2 | Molecular Weight | 244.16700 | |
| Density | 1.418g/cm3 | Boiling Point | 287.4ºC at 760 mmHg | |
| Molecular Formula | C11H7F3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 123.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Identification and functional characterization of novel feline cytochrome P450 2A.
Xenobiotica 45 , 503-10, (2015) 1. Cytochrome P450s are the major metabolizing enzymes for xenobiotics in humans and other mammals. Although the domestic cat Felis catus, an obligate carnivore, is the most common companion animal, the properties of cytochrome P450 subfamilies are largely un... |
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Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.
Expert Opin. Drug Metab. Toxicol. 10(10) , 1313-24, (2014) Drug resistance by Plasmodium falciparum remains a challenge in malaria chemotherapy. This paper will focus on physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid shown to have antimalarial activi... |
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Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.
Xenobiotica 44(7) , 615-26, (2014) 1. Cytochrome P450 enzyme system is the most important contributor to oxidative metabolism of drugs. Modification, and more specifically inhibition, of this system is an important determinant of several drug-drug interactions (DDIs). 2. Effects of the antimal... |
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Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.
J. Pharm. Sci. 104 , 2813-23, (2015) Asunaprevir (ASV; BMS-650032), a low nanomolar inhibitor of the hepatitis C virus (HCV) NS3 protease, is currently under development, in combination with other direct-acting antiviral (DAA) agents for the treatment of chronic HCV infection. Extensive nonclini... |
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Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents.
Xenobiotica 46 , 117-25, (2016) 1. Aegle marmelos (bael) is a popular tree in India and other Southeast Asian countries. The fruit is usually consumed as dried, fresh or juice, and is reported to have a high nutritional value and many perceived health benefits. Despite its edible nature and... |