U 19451A

U 19451A Structure
U 19451A structure
Common Name U 19451A
CAS Number 538-28-3 Molecular Weight 202.704
Density N/A Boiling Point 283.2ºC at 760mmHg
Molecular Formula C8H11ClN2S Melting Point 172-177 °C
MSDS Chinese USA Flash Point 125.1ºC
Symbol GHS06
GHS06
Signal Word Danger

S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase.

Bioorg. Med. Chem. Lett. 20 , 5126-9, (2010)

S-benzylisothiourea 3a was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit 3a lead to the identification of sub-muM inhibitors 3r and 10h, both of which suppressed kyn...