Phosphorus thiochloride
Phosphorus thiochloride structure
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Common Name | Phosphorus thiochloride | ||
|---|---|---|---|---|
| CAS Number | 3982-91-0 | Molecular Weight | 169.398 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 125.0±9.0 °C at 760 mmHg | |
| Molecular Formula | Cl3PS | Melting Point | -35 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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A new mechanism for nucleophilic substitution at a thiophosphoryl centre revealed by the reaction of diisopropylamine with PSCl3.
Chem. Commun. (Camb.) (22) , 2863-5, (2005) The reaction of PSCl3 with Pr(i)2NH at 60 degrees C affords the disubstitution product (Pr(i)2N)2P(S)Cl without first forming the monosubstitution product Pr(i)2NP(S)Cl2; a P(III) compound (possibly PCl3) generated in situ seems to be a crucial intermediate. |
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Hydrolysis studies of phosphodichloridate and thiophosphodichloridate ions.
J. Org. Chem. 77(13) , 5829-31, (2012) We report the pH-k(obs) profiles for the hydrolyses of phosphodichloridate and thiophosphodichloridate ions in aqueous solutions. Both species show broad pH-k(obs) plateaus that extend to high pHs. |
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Hapten synthesis for enzyme-linked immunoassay of the insecticide triazophos.
Anal. Biochem. 357(1) , 9-14, (2006) Two haptens of the insecticide triazophos (O,O-diethyl O-[1-phenyl-1H-1,2,4-triazol-3-yl] phosphorothioate) were synthesized by introducing appropriate spacers in the O-ethyl site of the analyte molecular structure. First, thiophosphoryl chloride (PSCl(3)) re... |
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Synthesis of bicoumarin thiophosphate derivatives as steroid sulfatase inhibitors.
Eur. J. Med. Chem. 101 , 358-66, (2015) Based on the frameworks of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one, a series of bicoumarin thiophosphate analogs have been syn... |
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[Hygienic substantiation of the maximum permissible level of phosphorus thiotrichloride in reservoir water].
Gig. Sanit. (11) , 68-70, (1988)
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The chemoselective one-step alkylation and isolation of thiophosphorylated cdk2 substrates in the presence of native cysteine.
ChemBioChem. 12(4) , 633-40, (2011) The elucidation of signalling pathways relies heavily upon the identification of protein kinase substrates. Recent investigations have demonstrated the efficacy of chemical genetics using ATP analogues and modified protein kinases for specific substrate label... |
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Short-term systems to assess thiophosphoryl chloride standards.
J. Appl. Toxicol. 4(5) , 230-5, (1984) The rat acute oral LD50 value of PSCl3 is 750 mg per kg body weight. A rat 90-day oral feeding study at dose levels of 7.5 mg (P1) and 37.5 mg (P5) per kg resulted in increased body weight gain. Other responses inconsistently varied between dose levels. At 7.... |
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Synthesis of [35S]thiophosphoryl adenylic acid, utilizing a general procedure for [35S]thiophosphoryl chloride production.
Anal. Biochem. 209(1) , 143-9, (1993) Elemental [35S]sulfur was shown to equilibrate with the sulfur of thiophosphoryl chloride when these materials are heated together. This isotopic exchange reaction is the basis of a convenient, microscale synthesis of high specific activity [35S]PSCl3. [35S]T... |
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The gas-phase on-line production of phosphorus thiotrihalides, SPX3 and their identification by infrared spectroscopy.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 58(8) , 1577-82, (2002) A new route has been devised, leading to the production of phosphorus thiotrihalides, SPX3 where X = F, Br and I by an on-line process using phosphorus thiotrichloride, SPCl3 as starting compound gassed over the following heated salts NaF, KBr and KI at 530, ... |