BENZINIDIC ACID METHYL ESTER HYDROCHLORIDE
BENZINIDIC ACID METHYL ESTER HYDROCHLORIDE structure
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Common Name | BENZINIDIC ACID METHYL ESTER HYDROCHLORIDE | ||
|---|---|---|---|---|
| CAS Number | 5873-90-5 | Molecular Weight | 171.62400 | |
| Density | N/A | Boiling Point | 171.1ºC at 760mmHg | |
| Molecular Formula | C8H10ClNO | Melting Point | 105-107ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 57.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.
Chem. Res. Toxicol. 20(4) , 701-8, (2007) Thiobenzamide (TB) is hepatotoxic in rats causing centrolobular necrosis, steatosis, cholestasis, and hyperbilirubinemia. It serves as a model compound for a number of thiocarbonyl compounds that undergo oxidative bioactivation to chemically reactive metaboli... |
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Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa.
J. Biol. Chem. 268(2) , 1066-73, (1993) Members of the snake venon-derived, "disintegrin" peptide family containing the Arg-Gly-Asp (RGD) amino acid sequence are among the most potent inhibitors of the binding of adhesive proteins to platelet glycoprotein (GP) IIb-IIIa. However, GPIIb-IIIa antagoni... |
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Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).
Bioorg. Med. Chem. Lett. 11(18) , 2533-6, (2001) Conformationally restricted benzamide bioisosteres were investigated when the chiral phenyldihydroimidazole derivative 4e (FAUC 179) showed strong and highly selective dopamine D4 receptor binding (K(i)high=0.95nM). Mitogenesis experiments indicated partial a... |