Spaglumic Acid
Spaglumic Acid structure
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Common Name | Spaglumic Acid | ||
|---|---|---|---|---|
| CAS Number | 3106-85-2 | Molecular Weight | 304.253 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 769.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C11H16N2O8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 419.1±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Differential effects of N-acetyl-aspartyl-glutamate on synaptic and extrasynaptic NMDA receptors are subunit- and pH-dependent in the CA1 region of the mouse hippocampus.
Neurobiol. Dis. 82 , 580-92, (2015) Ischemic strokes cause excessive release of glutamate, leading to overactivation of N-methyl-d-aspartate receptors (NMDARs) and excitotoxicity-induced neuronal death. For this reason, inhibition of NMDARs has been a central focus in identifying mechanisms to ... |
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Standardized method for high-resolution 1H-NMR of cerebrospinal fluid.
Clin. Chem. 41(5) , 744-51, (1995) This study describes a standardized method for recording single-pulse 1H-nuclear magnetic resonance (1H-NMR) spectra from cerebrospinal fluid (CSF). Quantitative data for alanine, valine, threonine, and lactic acid correlated well with data obtained with conv... |
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Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.
Clin. Biochem. 38(11) , 997-1008, (2005) To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis and screening of inborn errors of metabolism ... |
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N-acetylaspartylglutamate in Canavan disease: an adverse effector?
Eur. J. Pediatr. 158(5) , 406-9, (1999) We measured N-acetylaspartate and its precursor/product N-acetylaspartylglutamate (NAAG) in urine of patients with Canavan disease using capillary zone electrophoresis. Abnormal levels of NAAG were found in 32 of 43 patients examined. Elevated NAAG was also p... |
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Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis.
Ann. Neurol. 28(1) , 18-25, (1990) Recently, the excitatory amino acid neurotransmitter glutamate was implicated in the pathogenesis of a variety of chronic degenerative neurological diseases in humans and animals. This report describes abnormalities in excitatory amino acids in the central ne... |
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Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice.
Int. J. Neuropsychopharmacol. 17(8) , 1283-94, (2014) A novel N-acetyltransferase, Shati/Nat8l, was identified in the nucleus accumbens (NAc) of mice with methamphetamine (METH) treatment. Previously we reported that suppression of Shati/Nat8l enhanced METH-induced behavioral alterations via dopaminergic neurona... |
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To Break or to Brake Neuronal Network Accelerated by Ammonium Ions?
PLoS ONE 10 , e0134145, (2015) The aim of present study was to investigate the effects of ammonium ions on in vitro neuronal network activity and to search alternative methods of acute ammonia neurotoxicity prevention.Rat hippocampal neuronal and astrocytes co-cultures in vitro, fluorescen... |
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High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients.
Schizophr. Res. 91(1-3) , 14-21, (2007) Prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating, is decreased in schizophrenia. The validity of a glutamatergic, N-methyl-d-aspartate receptor (NMDAR)-mediated model of PPI disruption is presently equivocal. The NMDAR antagon... |
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[P-hydroxyphenylacetic acid concentrations in cerebrospinal fluid].
No. To Shinkei 34(8) , 769-74, (1982) Using reversed-phase high-performance liquid chromatography and electrochemical detection with a rapid one-step purification on Sephadex G-10 column, we have developed a sensitive technique to measure p-hydroxyphenylacetic acid (PHPA), the oxidatively deamina... |
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Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment.
Psychopharmacology 99(3) , 322-7, (1989) Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized admini... |