1,2,3,6-Tetrahydropyridine
1,2,3,6-Tetrahydropyridine structure
|
Common Name | 1,2,3,6-Tetrahydropyridine | ||
|---|---|---|---|---|
| CAS Number | 694-05-3 | Molecular Weight | 83.132 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 110.9±9.0 °C at 760 mmHg | |
| Molecular Formula | C5H9N | Melting Point | −48 °C(lit.) | |
| MSDS | USA | Flash Point | 16.1±0.0 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
|
The highly-selective 5-HT(1A) agonist F15599 reduces L-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque.
Neuropharmacology 97 , 306-11, (2015) L-3,4-dihydroxyphenylalanine (L-DOPA) is the most effective anti-parkinsonian agent available, but upon chronic administration, patients with Parkinson's disease (PD) experience abnormal involuntary movements, dyskinesia. Modulation of serotonin 1A (5-HT1A) r... |
|
|
Neuroprotective effects of 5-(4-hydroxy-3-dimethoxybenzylidene)-thiazolidinone in MPTP induced Parkinsonism model in mice.
Neuropharmacology 93 , 209-18, (2015) Parkinson's disease (PD) is a neurological disorder characterized by degeneration of nigrostriatal dopaminergic (DAergic) system. Present treatment targeting to DAergic system solely ameliorated the symptoms but failed to retard the DAergic neuron degeneratio... |
|
|
A new class of ammonium ylid for [2,3]-sigmatropic rearrangement reactions: ene-endo-spiro ylids.
Org. Lett. 7 , 2075, (2005) The first examples of sigmatropic rearrangements of ene-endo-spirocyclic, tetrahydropyridine-derived ammonium ylids are reported. Thus, spiro[6.7]-ylids rearrange primarily by a [2,3]-pathway, whereas the analogous [6.6]-ylids rearrange by [1,2]- and [2,3]-me... |
|
|
Disinhibitory recruitment of NMDA receptor pathways in retina.
J. Neurophysiol. 112(1) , 193-203, (2014) Glutamate release at bipolar to ganglion cell synapses activates NMDA and AMPA/kainic acid (KA) ionotropic glutamate receptors. Their relative strength determines the output signals of the retina. We found that this balance is tightly regulated by presynaptic... |