Paxilline
Paxilline structure
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Common Name | Paxilline | ||
|---|---|---|---|---|
| CAS Number | 57186-25-1 | Molecular Weight | 435.555 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 648.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H33NO4 | Melting Point | 252ºC | |
| MSDS | Chinese USA | Flash Point | 346.2±31.5 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Large-conductance calcium-activated potassium current modulates excitability in isolated canine intracardiac neurons.
Am. J. Physiol. Cell Physiol. 304(3) , C280-6, (2013) We studied principal neurons from canine intracardiac (IC) ganglia to determine whether large-conductance calcium-activated potassium (BK) channels play a role in their excitability. We performed whole cell recordings in voltage- and current-clamp modes to me... |
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Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts.
J. Physiol. Sci. 62(4) , 325-32, (2012) The mitochondrial calcium-activated potassium channel (mitoK(Ca)) and the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) are both involved in cardiac preconditioning. Here, we examined whether these two channels are also involved in ischemic or ph... |
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Methamphetamine inhibits voltage-gated potassium currents in NG108-15 cells: possible contribution of large-conductance calcium-activated potassium channels.
Toxicol. Lett. 223(2) , 139-45, (2013) Methamphetamine (MA), a highly abused amphetamine-like psychostimulant, has surged in popularity worldwide in the last decade. Repeated MA exposure has been shown to affect the alternative splice variant expression of large conductance Ca(2+)-activated K(+) (... |
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Cytoprotective action of the potassium channel opener NS1619 under conditions of disrupted calcium homeostasis.
Pharmacol. Rep. 63(1) , 176-83, (2011) Cytoprotective properties of potassium channel openers (KCOs) have been demonstrated in several models of cell injury, mainly in ischemia-reperfusion-induced damage of cardiac muscle. The mechanism responsible for the observed cytoprotection and the relative ... |
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Antecedent ethanol attenuates cerebral ischemia/reperfusion-induced leukocyte-endothelial adhesive interactions and delayed neuronal death: role of large conductance, Ca2+-activated K+ channels.
Microcirculation 17(6) , 427-38, (2010) EtOH-PC reduces postischemic neuronal injury in response to cerebral (I/R). We examined the mechanism underlying this protective effect by determining (i) whether it was associated with a decrease in I/R-induced leukocyte-endothelial adhesive interactions in ... |
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The mitochondrial Ca2+-activated K+ channel contributes to cardioprotection by limb remote ischemic preconditioning in rat
Life Sci. 88(23-24) , 1026-30, (2011) Aims To investigate the role of the mitochondrial Ca2+-activated K+ channel in cardioprotection induced by limb remote ischemic preconditioning. |
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Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats.
Am. J. Physiol. Heart Circ. Physiol. 300(2) , H507-13, (2011) Chronic hypoxia protects the heart against injury caused by acute oxygen deprivation, but its salutary mechanism is poorly understood. The aim was to find out whether cardiomyocytes isolated from chronically hypoxic hearts retain the improved resistance to in... |
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The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.
Am. J. Physiol. Lung Cell. Mol. Physiol. 303(11) , L956-66, (2012) Activation of taste receptors (TAS2Rs) by bitter taste agonists has been reported to cause bronchodilation. The aim of this study was to extend the information on the effects of bitter taste agonists on responses induced by different contractile mediators in ... |
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Paxilline enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5.
Exp. Mol. Med. 43(1) , 24-34, (2011) Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) induces apoptosis selectively in cancer cells while sparing normal cells. However, many cancer cells are resistant to TRAIL-induced cell death. Here, we report that paxilline, an indole alkaloid f... |
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Contribution of BK channels to action potential repolarisation at minimal cytosolic Ca2+ concentration in chromaffin cells.
Pflugers Arch. 462(4) , 545-57, (2011) BK channels modulate cell firing in excitable cells in a voltage-dependent manner regulated by fluctuations in free cytosolic Ca(2+) during action potentials. Indeed, Ca(2+)-independent BK channel activity has ordinarily been considered not relevant for the p... |