16-BETA-HYDROXYTESTOSTERONE
16-BETA-HYDROXYTESTOSTERONE structure
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Common Name | 16-BETA-HYDROXYTESTOSTERONE | ||
|---|---|---|---|---|
| CAS Number | 17528-90-4 | Molecular Weight | 304.42400 | |
| Density | 1.19g/cm3 | Boiling Point | 454.7ºC at 760 mmHg | |
| Molecular Formula | C19H28O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 242.9ºC | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Moderate coffee and alcohol consumption improves the estrogen metabolite profile in adjuvant treated breast cancer patients: a pilot study comparing pre- and post-operative levels.
Mol. Genet. Metab. 89(4) , 381-9, (2006) Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16alpha-hydroxyestrone (16alphaOHE1) ratio are at reduced risk for breast cancer and have a better prognosis. The aim was to identify factors associated with the ... |
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Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte co-cultures.
Xenobiotica 32(8) , 653-66, (2002) 1. Steroids are known to act as permissive factors in hepatocytes. This study shows that dexamethasone (DEX) is a permissive factor for induction of CYP2B1/2, CYP3A1, CYP2A1 and probably also CYP2C11 in cultures with primary rat hepatocytes. 2. The induction ... |
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Theoretical kinetics of sequential metabolism in vitro. Study of the formation of 16 alpha-hydroxyandrostenedione from testosterone by purified rat P450 2C11.
Drug Metab. Dispos. 22(4) , 584-91, (1994) P450 2C11 from rat liver is known to metabolize testosterone to 2 alpha-, 16 alpha-, and 6 beta-hydroxytestosterone, and to androstenedione and 16 alpha-hydroxyandrostenedione. Because Waxman (J. Biol. Chem. 259, 15481-15490) has reported that the enzyme conv... |
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High-performance liquid chromatographic determination of aromatization of 16 alpha-hydroxylated androgens with human placental microsomes.
Anal. Biochem. 146(1) , 75-81, (1985) A sensitive nonradiometric assay of aromatization of 16 alpha-hydroxylated androgens, 16 alpha-hydroxy-4-androstene-3,17-dione (16 alpha-OHA), and 16 alpha-hydroxytestosterone (16 alpha-OHT), has been developed using reverse-phase high-performance liquid chro... |
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Metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 in rat liver.
Biochem. Int. 28(3) , 543-50, (1992) The metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 system was studied with two different inductions. At least 5 different metabolites with higher polarity were produced from 16 alpha-hydroxytestosterone. MT-B, one of their products, appeared t... |
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A refined characterisation of the NeoHepatocyte phenotype necessitates a reappraisal of the transdifferentiation hypothesis
Differentiation 77(3) , 263-76, (2009) Under certain culture conditions human peripheral blood monocytes may be induced to express phenotypic markers of non-haematopoietic lineages, including hepatocyte-defining traits. One such example, the NeoHepatocyte, was previously shown to express a broad p... |
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Testosterone-metabolizing capacity and characteristics of adrenal microsomes in human fetus in vitro.
J. Pediatr. Endocrinol. Metab. 23(1-2) , 143-52, (2010) We describe the metabolite spectrum of testosterone (T) in human fetal adrenal in vitro, and verify possible roles of CYP3A and 2C isoforms of human fetal adrenal in T metabolism which respond to T metabolism in liver. Isolation and identification of T and it... |