Tryptanthrine
Tryptanthrine structure
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Common Name | Tryptanthrine | ||
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| CAS Number | 13220-57-0 | Molecular Weight | 248.23600 | |
| Density | 1.45g/cm3 | Boiling Point | 469.3ºC at 760 mmHg | |
| Molecular Formula | C15H8N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 237.7ºC | |
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Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP.
Arch. Biochem. Biophys. 542 , 14-20, (2014) Atopic dermatitis (AD) is a common skin disease that greatly worsens quality of life. Thymic stromal lymphopoietin (TSLP) plays a decisive role in the development of AD. The purpose of this study is to examine whether tryptanthrin (TR) would suppress AD throu... |
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Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells.
J. Ethnopharmacol. 174 , 474-81, (2015) Indigo naturalis has been used to treat inflammatory diseases and dermatosis, including psoriasis, since thousands of years in China. It has been proven effective in our previous clinical studies on treating psoriasis, but the active component and the mechani... |
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Kourokhitin, a potential drug containing two active substances.
Dokl. Biochem. Biophys. 426 , 131-3, (2009)
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Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
Antimicrob. Agents Chemother. 52(12) , 4466-9, (2008) New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanth... |
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LC-APCI-MS method for detection and analysis of tryptanthrin, indigo, and indirubin in daqingye and banlangen.
J. Pharm. Biomed. Anal. 43(1) , 346-51, (2007) A rapid, selective, and sensitive LC-APCI-MS method is developed in this study for detecting and analyzing tryptanthrin, indigo, and indirubin in daqingye and banlangen, which are, respectively, the leaves and roots of Isatis indigotica and Strobilanthes cusi... |
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Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives.
Bioorg. Med. Chem. Lett. 17(6) , 1769-72, (2007) Derivatives of indolo[2,1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl gro... |
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Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells
Chem. Biol. Interact. 203(2) , 512-21, (2013) Graphical abstract [Display omitted] |
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One-pot synthesis of simple alkaloids: 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine.
Chem. Pharm. Bull. 56(4) , 607-9, (2008) One-pot synthesis of various 2,3-polymethylene-4(3H)-quinazolinones from anthranilic acid, corresponding lactam and SOCl(2) is described, which can be applicable to the synthesis of simple 4(3H)-quinazolinone-derived alkaloids, such as luotonin A, tryptanthri... |
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Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells.
J. Ethnopharmacol. 134(2) , 450-9, (2011) Tryptanthrin is a compound isolated from Polygonum tinctorium, which is a known folk medicine with various biological activities.Allergic diseases are initiated by the development of allergen-specific T helper type 2 (Th2) cells and amplified by the degranula... |
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Amino acid salts catalyzed asymmetric aldol reaction of tryptanthrin: a straightforward synthesis of phaitanthrin A and its derivatives.
Org. Lett. 15(18) , 4738-41, (2013) The first asymmetric synthesis of (S)-Phaitanthrin A and its derivatives via a catalytic aldol reaction of Tryptanthrin and ketones is described, in which the cheap, easily prepared natural amino acid salts exhibited unique catalytic ability; importantly, thi... |