Thapsigargin
Thapsigargin structure
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Common Name | Thapsigargin | ||
|---|---|---|---|---|
| CAS Number | 67526-95-8 | Molecular Weight | 650.754 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 699.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C34H50O12 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 209.0±25.0 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells.
Biochim. Biophys. Acta 1853(2) , 377-87, (2015) Macroautophagy (autophagy) is an important factor affecting the function of vascular endothelial cells (VECs) and must be tightly regulated in these cells. However, the precise mechanisms underlying this process, particularly in the presence of serum, remain ... |
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Identification of the cellular mechanisms that modulate trafficking of frizzled family receptor 4 (FZD4) missense mutants associated with familial exudative vitreoretinopathy.
Invest. Ophthalmol. Vis. Sci. 55(6) , 3423-31, (2014) Fifteen missense mutations in the frizzled family receptor 4 (FZD4) reported to cause familial exudative vitreoretinopathy (FEVR) were evaluated to establish the pathological cellular mechanism of disease and to explore novel therapeutic strategies.The mutati... |
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Improved plasma membrane expression of the trafficking defective P344R mutant of muscle, skeletal, receptor tyrosine kinase (MuSK) causing congenital myasthenic syndrome.
Int. J. Biochem. Cell Biol. 60 , 119-29, (2015) Muscle, skeletal, receptor tyrosine kinase (MuSK) is a key organizer at the postsynaptic membrane and critical for proper development and maintenance of the neuromuscular junction. Mutations in MUSK result in congenital myasthenic syndrome (CMS). We hypothesi... |
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mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling.
Addict. Biol. 20 , 927-40, (2015) Emerging evidence indicates that metabotropic glutamate receptor 5 (mGluR5) critically modulates drug and drug-related behaviors. However, the role of mGluR5 in the opiate-induced contextual memory remains unclear. Here, we found that microinfusion of the mGl... |
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Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes.
Arthritis Rheumatology 66(5) , 1266-71, (2014) Nuclear protein 1 (Nupr1) is a stress-inducible protein that is involved in gene transcription. The present study was undertaken to determine whether chondrocytes express Nupr1 and whether Nupr1 regulates matrix metalloproteinase 13 (MMP-13) expression.Paraff... |
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The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells.
Oncotarget 5(15) , 6252-66, (2014) Velcade is one of the inescapable drug to treat patient suffering from multiple myeloma (MM) and resistance to this drug represents a major drawback for patients. However, the mechanisms underlying velcade resistance remain incompletely understood. We derived... |
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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.
Sci. Signal. 8 , ra113, (2015) Skeletal muscle is the largest organ, comprising 40% of the total body lean mass, and affects whole-body metabolism in multiple ways. We investigated the signaling pathways involved in this process using TSCmKO mice, which have a skeletal muscle-specific depl... |
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Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation.
Biomaterials 60 , 82-91, (2015) A hallmark of mature mammalian ventricular myocardium is a positive force-frequency relationship (FFR). Despite evidence of organotypic structural and molecular maturation, a positive FFR has not been observed in mammalian tissue engineered heart muscle. We h... |
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WNT16-expressing Acute Lymphoblastic Leukemia Cells are Sensitive to Autophagy Inhibitors after ER Stress Induction.
Anticancer Res. 35 , 4625-31, (2015) Previous work from our group showed hypoxia can induce endoplasmic reticulum (ER) stress and block the processing of the WNT3 protein in cells engineered to express WNT3a. Acute lymphoblastic leukemia (ALL) cells with the t(1:19) translocation express the WNT... |
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Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.
PLoS Pathog. 11 , e1004946, (2015) Pseudomonas aeruginosa infection can be disastrous in chronic lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease. Its toxic effects are largely mediated by secreted virulence factors including pyocyanin, elastase and alkaline prot... |