Ac-D-Ala-OH

Ac-D-Ala-OH Structure
Ac-D-Ala-OH structure
Common Name Ac-D-Ala-OH
CAS Number 19436-52-3 Molecular Weight 131.130
Density 1.2±0.1 g/cm3 Boiling Point 369.7±25.0 °C at 760 mmHg
Molecular Formula C5H9NO3 Melting Point 128 °C
MSDS Chinese USA Flash Point 177.4±23.2 °C

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).

Bioorg. Med. Chem. 16 , 10061-74, (2008)

Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and ...

Crystal structures of the complexes between vancomycin and cell-wall precursor analogs.

J. Mol. Biol. 385 , 1422-1432, (2009)

The crystal structures of three vancomycin complexes with two vancomycin-sensitive cell-wall precursor analogs (diacetyl-Lys-D-Ala-D-Ala and acetyl-D-Ala-D-Ala) and a vancomycin-resistant cell-wall precursor analog (diacetyl-Lys-D-Ala-D-lactate) were determin...

Displacement study on a vancomycin-based stationary phase using N-acetyl-D-alanine as a competing agent.

J. Chromatogr. Sci. 40 , 83-86, (2002)

The analysis of the binding data of D,L-dansyl amino acids on a vancomycin stationary phase is investigated in relation to the addition of N-acetyl-D-alanine in the mobile phase. This eluent additive acts as a specific competing agent for the aglycone pocket ...

A ligand-mediated dimerization mode for vancomycin.

Chem. Biol. 5 , 293-298, (1998)

Vancomycin and related glycopeptide antibiotics exert their antimicrobial effect by binding to carboxy-terminal peptide targets in the bacterial cell wall and preventing the biosynthesis of peptidoglycan. Bacteria can resist the action of these agents by repl...