TRH
TRH structure
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Common Name | TRH | ||
|---|---|---|---|---|
| CAS Number | 24305-27-9 | Molecular Weight | 362.38 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 942.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C16H22N6O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 523.6±34.3 °C | |
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Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny.
J. Endocrinol. 224(3) , 315-25, (2015) Postnatal nicotine exposure leads to obesity and hypothyroidism in adulthood. We studied the effects of maternal nicotine exposure during lactation on thyroid hormone (TH) metabolism and function in adult offspring. Lactating rats received implants of osmotic... |
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Microbial community analysis of switchgrass planted and unplanted soil microcosms displaying PCB dechlorination.
Appl. Microbiol. Biotechnol. 99 , 6515-26, (2015) Polychlorinated biphenyls (PCBs) pose potential risks to human and environmental health because they are carcinogenic, persistent, and bioaccumulative. In this study, we investigated bacterial communities in soil microcosms spiked with PCB 52, 77, and 153. Sw... |
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Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood.
J. Endocrinol. 226 , 219-26, (2015) Early overnutrition (EO) during lactation leads to obesity, leptin resistance and lower thyroid hormone (TH) levels during adulthood. To better understand the biological significance of this thyroid hypofunction, we studied the long-term effects of postnatal ... |
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A Novel Europium Chelate Coated Nanosphere for Time-Resolved Fluorescence Immunoassay.
PLoS ONE 10 , e0129689, (2015) A novel europium ligand 2,2',2'',2'''-(4,7-diphenyl-1,10-phenanthroline-2,9-diyl) bis (methylene) bis (azanetriyl) tetra acetic acid (BC-EDTA) was synthesized and characterized. It shows an emission spectrum peak at 610 nm when it is excited at 360 nm, with a... |
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IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
Biol. Chem. 397 , 45-55, (2015) Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This modification is catalyzed by the glutaminyl cyclases QC and isoQC. Here, we decipher the roles of the isoenzymes by characterization of IsoQC-/- ... |
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Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues.
Nat. Commun. 6 , 6208, (2015) Nanostructured porous silicon (PSi) is emerging as a promising platform for drug delivery owing to its biocompatibility, degradability and high surface area available for drug loading. The ability to control PSi structure, size and porosity enables programmin... |
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Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647.
Mol. Pharm. 9(9) , 2458-68, (2012) The present study, in general, is aimed to uncover the properties of the transport mechanism or mechanisms responsible for the uptake of NP-647 into Caco-2 cells and, in particular, to understand whether it is a substrate for the intestinal oligopeptide trans... |
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Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor.
Bioorg. Med. Chem. 23(8) , 1841-8, (2015) The synthesis, characterization, and use of Eu-DTPA-PEGO-Trp-Nle-Asp-Phe-NH2 (Eu-DTPA-PEGO-CCK4), a luminescent probe targeted to cholecystokinin 2 receptor (CCK2R, aka CCKBR), are described. The probe was prepared by solid phase synthesis. A Kd value of 17±2... |
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Trigonal scaffolds for multivalent targeting of melanocortin receptors.
Org. Biomol. Chem. 13(6) , 1778-91, (2015) Melanocortin receptors can be used as biomarkers to detect and possibly treat melanoma. To these ends, molecules bearing one, two, or three copies of the weakly binding ligand MSH(4) were attached to scaffolds based on phloroglucinol, tripropargylamine, and 1... |
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Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors.
J. Med. Chem. 58 , 5649-73, (2015) Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the dependence of thes... |