Cinobufotalin
Cinobufotalin structure
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Common Name | Cinobufotalin | ||
|---|---|---|---|---|
| CAS Number | 1108-68-5 | Molecular Weight | 458.544 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 627.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H34O7 | Melting Point | 259 - 262ºC | |
| MSDS | Chinese USA | Flash Point | 210.7±25.0 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent.
Biochem. Biophys. Res. Commun. 452(3) , 768-74, (2014) Lung cancer is a major cause of cancer-related mortality in the United States and around the world. Due to the pre-existing or acquired chemo-resistance, the current standard chemotherapy regimens only show moderate activity against lung cancer. In the curren... |
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Ceramide production mediates cinobufotalin-induced growth inhibition and apoptosis in cultured hepatocellular carcinoma cells.
Tumour Biol. 36 , 5763-71, (2015) Hepatocellular carcinoma (HCC) is a highly aggressive and lethal neoplasm with poor prognosis. The aim of this study is to investigate the anticancer activity of cinobufotalin, a bufadienolide isolated from toad venom, in cultured HCC cells, and to study the ... |
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Comparative Analysis of the Bufonis Venenum by Using TLC, HPLC, and LC-MS for Different Extraction Methods.
J Pharmacopuncture 15 , 52-65, (2015) Toad venom, called Chan-Su, is a traditional Oriental medicine secreted from the auricular and the skin glands of the Bufo bufo gargarizanz Cantor or B. melanosticus Schneider and has been widely used in China, Korea and other parts of Asia for the treatment ... |
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Chemical defense of an Asian snake reflects local availability of toxic prey and hatchling diet.
J. Zool. (Lond.) 289 , 270-278, (2013) Species that sequester toxins from prey for their own defense against predators may exhibit population-level variation in their chemical arsenal that reflects the availability of chemically defended prey in their habitat. Rhabdophis tigrinus is an Asian snake... |
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[Inhibitory effects of co-cinobufotalin oral liquor on hepatitis B in vitro].
Zhongguo Zhong Xi Yi Jie He Za Zhi 16(12) , 738-40, (1996) Co-Cinobufotalin Oral Liquor (CCOL) was studied for its ability to inhibit hepatitis B virus DNA replication, HBsAg and HBeAg expression in a HBV-transfected cell line (2.2.15 cell). The result showed that ID50 (the drug concentration that inhibits HBsAg or H... |
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[Clinical study on cinobufotalin in treating chronic hepatitis B virus carriers].
Zhongguo Zhong Xi Yi Jie He Za Zhi 13(8) , 473-5, 453-4, (1993) In a preliminary study, carriers of hepatitis B virus were treated with Cinobufotalin, a preparation from toad, for 1-3 course of treatment. Results indicated that negative conversion rate was markedly higher in the treated groups (21.09%, 38.89%, 63.64% and ... |
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[Effect of cinobufotalin on growth of xenograft of endometrial carcinoma cell line ishikawa in nude mouse and its impact on RRM2 expression].
Zhongguo Zhong Xi Yi Jie He Za Zhi 30(11) , 1183-5, (2010) To investigate the inhibitory effect of cinobufotalin (CBT) on the growth of xenograft endometrial carcinoma cell line ishikawa in nude mice, and its impact on the expression of ribonucleotide reductase subunit M2 (RRM2).Eleven nude mice with xenograft were r... |
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[Effect of cinobufagin on the expressions of bcl-2 mRNA and bax mRNA and the proliferation of lens epithelial cells].
Zhongguo Zhong Xi Yi Jie He Za Zhi 29(10) , 915-7, (2009) To investigate the effect of cinobufagin on the proliferation of lens epithelial cells (LECs) and the bcl-2 and bax mRNA expressions of rabbits.Cultured LECs were treated for 72 h with cinobufagin of different concentrations, the end titer was 0.1 mg/L for lo... |
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[Effect of traditional Chinese medicine on quality of life and survival period in patients with progressive gastric cancer].
Zhongguo Zhong Xi Yi Jie He Za Zhi 28(2) , 105-7, (2008) To investigate the effect of traditional Chinese medicine (TCM) on quality of life (QOF) and survival period in patients with progressive gastric cancer, and thus exploring its clinical efficacy.TCM therapy applied in the 34 patients assigned in the TCM group... |
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Microbial transformation of cinobufagin by Syncephalastrum racemosum.
J. Nat. Prod. 71 , 1268-70, (2008) Microbial transformation of a cytotoxic bufadienolide, cinobufagin (1), was performed by Syncephalastrum racemosum. The six metabolites obtained were identified as 7beta-hydroxycinobufagin ( 2), 12beta-hydroxycinobufagin (3), cinobufotalin (4), 5,12beta-dihyd... |