4-Nitrobenzyl chloride
4-Nitrobenzyl chloride structure
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Common Name | 4-Nitrobenzyl chloride | ||
|---|---|---|---|---|
| CAS Number | 100-14-1 | Molecular Weight | 171.581 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 292.5±15.0 °C at 760 mmHg | |
| Molecular Formula | C7H6ClNO2 | Melting Point | 71 °C | |
| MSDS | Chinese USA | Flash Point | 130.7±20.4 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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A heme model system for the reduction of substrates by microsomal cytochrome P 450.
Biochem. Biophys. Res. Commun. 104(4) , 1651-7, (1982)
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A case of multiple sensitization to three halogeno-substituted mono-nitrobenzenes.
Ital. Gen. Rev. Dermatol. 15(2) , 107-12, (1978) A case of occupational contact dermatitis in a female chemical pharmaceutical laboratory researcher is described. The allergological investigation revealed a state of sensitization to three mono-nitrobenzenes with halogen substitutions in the nucleus or a sid... |
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Hepatic and branchial glutathione S-transferases of two fish species: substrate specificity and biotransformation of microcystin-LR.
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 149(4) , 515-23, (2009) Liver and gills of roach (Rutilus rutilus) and silver carp (Hypophthalmichthys molitrix) were examined for glutathione S-transferases (GSTs) contents and their substrate specificity and capacity to biotransform microcystin-LR (MC-LR). GSTs and other glutathio... |
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Reactivity, SCE induction and mutagenicity of benzyl chloride derivatives.
J. Appl. Toxicol. 3(4) , 203-7, (1983) Benzyl chloride, benzyl bromide, p-methylbenzyl chloride, and p-nitrobenzyl chloride were used to study chemical reactivity with 4-(p-nitrobenzyl)-pyridine (NBP), and with guanosine in vitro, in relation to mutagenic potency in S. typhimurium and sister chrom... |
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Evaluation of hepatic glutathione transferase Mu 1 and Theta 1 activities in humans and mice using genotype information.
Drug Metab. Dispos. 40(3) , 497-503, (2012) We investigated the impact of glutathione transferases Mu 1 (GSTM1)- and glutathione transferase Theta 1 (GSTT1)-null genotypes on hepatic GST activities in humans and compared the results with those of Gstm1- and Gstt1-null mice. In liver with GSTM1/Gstm1-nu... |
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Glutathione S-transferase mediated detoxification and bioactivation of xenobiotics during early human pregnancy.
Early Hum. Dev. 37(3) , 167-74, (1994) Glutathione S-transferase (GST) with activity towards CDNB as a substrate from human intrauterine conceptual tissues (HICT) at 6-10 weeks of gestation was purified approximately 200-fold by GSH coupled Sepharose 4B affinity chromatography. The preparations of... |
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Tetrahedron Lett. 34 , 95, (1993)
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Reduction of benzyl halides by liver microsomes. Formation of 478 NM-absorbing sigma-alkyl-ferric cytochrome P-450 complexes.
Biochem. Pharmacol. 32(12) , 1871-9, (1983) The benzyl halides benzyl bromide and 4-nitrobenzyl chloride are reduced anaerobically by NADPH and rat liver microsomes to yield toluene and 4-nitrotoluene, respectively. These reductions and cytochrome P-450-dependent since they are inhibited by CO and mety... |
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[Subcellular distribution of glutathione S-transferase in Chinese fetal liver].
Zhongguo Yao Li Xue Bao 11(5) , 389-91, (1990) Subcellular fractions were isolated from Chinese fetal liver at 4-8 months of age for the determination of glutathione S-transferase (GST). Using 1-chloro-2,4-dinitrobenzene (CDNB) as substrate, GST activity was found to be 66 +/- 34 nmol/(min.mg protein), ma... |
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An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes.
J. Mol. Biol. 318(1) , 59-70, (2002) The correlation between sequence diversity and enzymatic function was studied in a library of Theta class glutathione transferases (GSTs) obtained by stochastic recombination of fragments of cDNA encoding human GST T1-1 and rat GST T2-2. In all, 94 randomly p... |