Acetaldoxime
Acetaldoxime structure
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Common Name | Acetaldoxime | ||
|---|---|---|---|---|
| CAS Number | 107-29-9 | Molecular Weight | 59.067 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 114.5±3.0 °C at 760 mmHg | |
| Molecular Formula | C2H5NO | Melting Point | 44-46 °C | |
| MSDS | Chinese USA | Flash Point | 40.0±0.0 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Warning | |
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Cyanogenesis in glucosinolate-producing plants: Carica papaya and Carica quercifolia.
Phytochemistry 60(3) , 269-73, (2002) (R)-2-(beta-D-Glucopyranosyloxy)-2-phenylacetonitrile (prunasin) was isolated from Carica papaya L. and C. quercifolia (A. St.-Hil.) Hieron. (syn. C. hastata Brign.). Earlier reported presence of cyclopentanoid cyanohydrin glycosides in C. papaya could not be... |
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Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor.
J. Med. Chem. 52 , 6032-41, (2009) Mammalian serine racemase (SR) is a pyridoxal-5'-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) receptors in the CNS. Aberrant regulation of NMDA receptor signali... |
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Distribution of aldoxime dehydratase in microorganisms.
Appl. Environ. Microbiol. 66(6) , 2290-6, (2000) The distribution of phenylacetaldoxime-degrading and pyridine-3-aldoxime-degrading ability was examined with intact cells of 975 microorganisms, including 45 genera of bacteria, 11 genera of actinomyces, 22 genera of yeasts, and 37 genera of fungi, by monitor... |
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Regulation of aldoxime dehydratase activity by redox-dependent change in the coordination structure of the aldoxime-heme complex.
J. Biol. Chem. 280(7) , 5486-90, (2005) Phenylacetaldoxime dehydratase from Bacillus sp. strain OxB-1 (OxdB) catalyzes the dehydration of Z-phenylacetaldoxime (PAOx) to produce phenylacetonitrile. OxdB contains a protoheme that works as the active center of the dehydration reaction. The enzymatic a... |
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Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives as novel antitubulin agents.
Bioorg. Med. Chem. 20(10) , 3233-41, (2012) A series of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives (1h-20h) have been designed and synthesized, and their biological activities were also evaluated as potential antiproliferation and tubulin polymerization inhibitors. Among all the ... |
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Anion-driven conformation control and enhanced sulfate binding utilising aryl linked salicylaldoxime dicopper helicates.
Dalton Trans. 40(45) , 12235-41, (2011) The synthesis and spectroscopic analysis of both "metal-only" and anion encapsulated dicopper(II) double helicates utilising a new 1,4-aryl spacer is described. X-Ray crystallographic analysis of the complexes reveal that the aromatic spacer increases rigidit... |
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Why is the oxidation state of iron crucial for the activity of heme-dependent aldoxime dehydratase? A QM/MM study.
J. Phys. Chem. B 116(31) , 9396-408, (2012) Aldoxime dehydratase is a heme-containing enzyme that utilizes the ferrous rather than the ferric ion to catalyze the synthesis of nitriles by dehydration of the substrate. We report a theoretical study of this enzyme aimed at elucidating its catalytic mechan... |
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Tungstate sulfuric acid (TSA)/KMnO4 as a novel heterogeneous system for rapid deoximation.
Molecules 11(9) , 720-5, (2006) Neat chlorosulfonic acid reacts with anhydrous sodium tungstate to give tungstate sulfuric acid (TSA), a new dibasic inorganic solid acid in which two sulfuric acid molecules connect to a tungstate moiety via a covalent bond. A variety of oximes were oxidized... |
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Vasorelaxant activity of some oxime derivatives.
Eur. J. Pharmacol. 575(1-3) , 122-6, (2007) Several non-aromatic substituted oxime derivatives (formamidoxime, acetaldoxime, acetone oxime, acetohydroxamic acid, formaldoxime) function as vasorelaxant NO donors when added to precontracted aortic rings in vitro. This study was aimed to evaluate whether ... |
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Systematic regulation of the enzymatic activity of phenylacetaldoxime dehydratase by exogenous ligands.
ChemBioChem. 7(12) , 2004-9, (2006) Phenylacetaldoxime dehydratase from Bacillus sp. OxB-1 (OxdB) contains a heme that acts as the active site for the dehydration reaction of aldoxime. Ferrous heme is the active form, in which the heme is five coordinate with His282 as a proximal ligand. In thi... |