BLT-1
BLT-1 structure
|
Common Name | BLT-1 | ||
|---|---|---|---|---|
| CAS Number | 321673-30-7 | Molecular Weight | 241.39600 | |
| Density | 1.14±0.1 g/cm3 | Boiling Point | 359.6±25.0 °C | |
| Molecular Formula | C12H23N3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
|
Intestinal scavenger receptors are involved in vitamin K1 absorption.
J. Biol. Chem. 289(44) , 30743-52, (2014) Vitamin K1 (phylloquinone) intestinal absorption is thought to be mediated by a carrier protein that still remains to be identified. Apical transport of vitamin K1 was examined using Caco-2 TC-7 cell monolayers as a model of human intestinal epithelium and in... |
|
|
NOX2-derived ROS-mediated surface translocation of BLT1 is essential for exocytosis in human eosinophils induced by LTB4.
Int. Arch. Allergy Immunol. 165(1) , 40-51, (2014) Leukotriene B4 (LTB4) is a proinflammatory lipid mediator that elicits eosinophil exocytosis, leading to allergic inflammation. However, the detailed intracellular signaling mechanisms of eosinophil exocytosis induced by LTB4 are poorly understood. Herein, we... |
|
|
Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⁺ T cells.
Immunology 146 , 50-8, (2015) Leukotriene B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common inflammatory skin disease characterized by skin oedema and abund... |
|
|
Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states.
Am. J. Physiol. Gastrointest. Liver Physiol. 309 , G350-9, (2015) The small intestine contributes to diabetic dyslipidemia through the overproduction of apolipoprotein B48 (apoB48)-containing chylomicron particles. An important regulator of chylomicron generation is dietary lipid absorption, underlining the potential involv... |
|
|
Influence of PD-L1 cross-linking on cell death in PD-L1-expressing cell lines and bovine lymphocytes.
Immunology 142(4) , 551-61, (2014) Programmed death-ligand 1 (PD-L1) blockade is accepted as a novel strategy for the reactivation of exhausted T cells that express programmed death-1 (PD-1). However, the mechanism of PD-L1-mediated inhibitory signalling after PD-L1 cross-linking by anti-PD-L1... |
|
|
Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth.
Nat. Commun. 6 , 7064, (2015) Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study, we demonstrate that in K-ras(LA1) mice, CS exposure markedly enhances the lung tumour burden and ge... |
|
|
Cellular cholesterol transport proteins in diabetic nephropathy.
PLoS ONE 9(9) , e105787, (2014) Lipid accumulation has been shown to accelerate renal injury, and the intracellular accumulation of lipids may be caused by alterations in synthesis as well as lipid uptake and efflux. We have investigated the role of cellular cholesterol transport proteins i... |
|
|
Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation.
BMC Immunol. 9 , 36, (2008) Leukotriene B4 (LTB4) is a potent inflammatory mediator that also stimulates the immune response. In addition, it promotes polymorphonuclear leukocyte phagocytosis, chemotaxis, chemokinesis and modulates cytokines release. Regarding chemical instability of th... |
|
|
Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development.
Breast Cancer Res. 15 , R87, (2014) Previous studies have identified cholesterol as an important regulator of breast cancer development. High-density lipoprotein (HDL) and its cellular receptor, the scavenger receptor class B type I (SR-BI) have both been implicated in the regulation of cellula... |
|
|
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.
J. Exp. Med. 201 , 1961-71, (2005) Mast cells are tissue-resident cells with important functions in allergy and inflammation. Pluripotential hematopoietic stem cells in the bone marrow give rise to committed mast cell progenitors that transit via the blood to tissues throughout the body, where... |