Ginsenoside Rf

Ginsenoside Rf Structure
Ginsenoside Rf structure
Common Name Ginsenoside Rf
CAS Number 52286-58-5 Molecular Weight 801.013
Density 1.3±0.1 g/cm3 Boiling Point 912.3±65.0 °C at 760 mmHg
Molecular Formula C42H72O14 Melting Point N/A
MSDS Chinese USA Flash Point 505.5±34.3 °C
Symbol GHS07
GHS07
Signal Word Warning

Determination of ginsenoside Rf and Rg2 from Panax ginseng using enzyme immunoassay.

Chem. Pharm. Bull. 46(7) , 1144-7, (1998)

We have developed an enzyme immunoassay (EIA) to quantify trace amounts of ginsenoside Rf (Rf), one of the glycosides of protopanaxatriol from Panax ginseng. A carrier protein of bovine serum albumin (BSA) was coupled to the carbohydrate component of Rf using...

[Practical optimization of the two-dimensional thin-layer chromatographic separation of ginsenosides].

Se Pu 18(6) , 546-9, (2000)

A computer-assisted method is presented for optimization of mobile phase selection for separation of the mixture of ginsenosides in two-dimensional TLC. This method bases on the correlation between the proportions of mobile phases and the retention values Rf ...

Microbial conversion of rare ginsenoside Rf to 20(S)-protopanaxatriol by Aspergillus niger.

Biosci. Biotechnol. Biochem. 74(1) , 96-100, (2010)

In this study, rare ginsenoside Rf was transformed into 20(S)-protopanaxatriol (PPT(S)) by glycosidase from Aspergillus niger. By investing the reaction conditions, the optimal conditions were obtained, as follows: pH 5.0, temperature 55 degrees C, and substr...

Biotransformation of ginsenoside Rf to Rh1 by recombinant beta-glucosidase.

Molecules 14(6) , 2043-8, (2009)

An Aspergillus niger strain was isolated from the soil around ginseng fruit. In vitro enzyme assays showed that this strain had the ability to transform total ginsenosides (TGS) into several new products. In a further biochemical study, a beta-glucosidase gen...

[A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng].

Yao Xue Xue Bao 43(12) , 1211-6, (2008)

Current quality control patterns are limited to industrial application, for most of the natural chemical reference substances are expensive and unavailable. Herein, a method, quantitative analysis of multi-components with single marker (QAMS), was established...

Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice.

Life Sci. 72(7) , 759-68, (2003)

In the present study, the effect of ginsenoside Rf (Rf), a trace component of Panax ginseng on U-50,488H (U50), a selective kappa opioid-induced analgesia and its tolerance to analgesia was studied using the mice tail-flick test. In addition, the possible mec...

Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes.

Acta Pharmacol. Sin. 26(5) , 551-8, (2005)

To examine the effects of ginseng saponins on the heterologously expressed human ether-a-go-go related gene (HERG) that encodes the rapid component of the delayed rectifier K+ channel.A two-electrode voltage clamp technique was used. HERG currents were record...

Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha.

Biochem. Biophys. Res. Commun. 339(1) , 196-203, (2006)

We investigated whether ginseng regulates lipoprotein metabolism by altering peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated pathways, using a PPARalpha-null mouse model. Administration of ginseng extract, ginsenosides, and ginsenoside R...

Ginsenoside Rf2, a new dammarane glycoside from Korean red ginseng (Panax ginseng).

Arch. Pharm. Res. 21(5) , 615-7, (1998)

A new dammarane glycoside named ginsenoside Rf2 has been isolated from Korean red ginseng (Panax ginseng) and its chemical structure has been elucidated as 6-O-[alpha-L-rhamnopyranosyl (1-->2) beta-D-glucopyranosyl]dammarane-3 beta, 6 alpha, 12 beta, 20(R), 2...

Preparation of monoclonal antibody against ginsenoside Rf and its enzyme immunoassay.

Biol. Pharm. Bull. 23(5) , 523-6, (2000)

A rapid and sensitive indirect competitive enzyme immunoassay method has been developed for quantitating ginsenoside Rf (Rf) in crude total Panax ginseng saponins and in rat plasma using high titer mouse monoclonal antibody (mAb) raised against a conjugate of...