LFM-A13
LFM-A13 structure
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Common Name | LFM-A13 | ||
|---|---|---|---|---|
| CAS Number | 244240-24-2 | Molecular Weight | 360.001 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 487.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C11H8Br2N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 248.9±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
EMBO Mol. Med. 7(3) , 240-58, (2015) Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacro... |
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Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells.
Mol. Cancer 9 , 267, (2010) Recently, much attention has been focused on gaining a better understanding of the different populations of cells within a tumor and their contribution to cancer progression. One of the most commonly used methods to isolate a more aggressive sub-population of... |
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Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.
J. Exp. Med. 206(4) , 937-52, (2009) Differentiation and recruitment of alternatively activated macrophages (AAMacs) are hallmarks of several inflammatory conditions associated with infection, allergy, diabetes, and cancer. AAMacs are defined by the expression of Arginase 1, chitinase-like molec... |
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'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47.
PLoS ONE 8 , e77615, (2013) SIRPα, an ITIMs-containing signaling receptor, negatively regulates leukocyte responses through extracellular interactions with CD47. However, the dynamics of SIRPα-CD47 interactions on the cell surface and the governing mechanisms remain unclear. Here we rep... |
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Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages.
J. Inflamm. (Lond.) 3 , 8, (2006) Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation. Receptors recognising various microbes have been identified, but the signalling pathways are not e... |
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Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
J. Exp. Med. 209 , 407-21, (2012) Neutrophils trigger inflammation-induced acute kidney injury (AKI), a frequent and potentially lethal occurrence in humans. Molecular mechanisms underlying neutrophil recruitment to sites of inflammation have proved elusive. In this study, we demonstrate that... |
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Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation.
J. Cell Biol. 182 , 753-63, (2008) Mechanosensing followed by mechanoresponses by cells is well established, but the mechanisms by which mechanical force is converted into biochemical events are poorly understood. Vascular endothelial cells (ECs) exhibit flow- and stretch-dependent responses a... |
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Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F.
J. Cell. Mol. Med. 17 , 265-76, (2013) The Janus kinase 2 mutant V617F occurs with high frequency in myeloproliferative neoplasms. Further mutations affecting the Janus kinase family have been discovered mostly in leukaemias and in myeloproliferative neoplasms. Owing to their involvement in neopla... |
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Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells.
J. Exp. Med. 201 , 1837-52, (2005) Pre-B cells undergo apoptosis unless they are rescued by pre-B cell receptor-dependent survival signals. We previously showed that the BCR-ABL1 kinase that is expressed in pre-B lymphoblastic leukemia bypasses selection for pre-B cell receptor-dependent survi... |